AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

被引：0

作者：

Joungmok Kim

Mondira Kundu

Benoit Viollet

Kun-Liang Guan

机构：

[1] University of California at San Diego,Department of Pharmacology and Moores Cancer Center

[2] St. Jude Children's Hospital,Department of Pathology

[3] INSERM U1016,undefined

[4] Institut Cochin,undefined

[5] Université Paris Descartes,undefined

[6] CNRS (UMR 8104),undefined

来源：

Nature Cell Biology | 2011年 / 13卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A molecular mechanism that links the mTOR and autophagy pathways is now revealed. Depending on nutrient availability, the AMPK and mTOR kinases differentially phosphorylate the autophagy-initiating kinase Ulk1 to regulate its activity.

引用

页码：132 / 141

页数：9

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