Application of Enzymatic Promiscuity in Pharmaceutical Synthesis: Papain-catalyzed One-pot Synthesis of 1,4-Dihydropyridine Calcium Channel Antagonists and Derivatives

被引：0

作者：

Ling Jiang

Wenting Ye

Weike Su

Chuanming Yu

机构：

[1] Zhejiang University of Technology,Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals

[2] Zhejiang University of Technology,Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences

来源：

Chemical Research in Chinese Universities | 2019年 / 35卷

关键词：

Papain; Catalytic promiscuity; Multicomponent reaction; 1,4-Dihydropyridine calcium channel antagonist;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP) calcium channel antagonists felodipine, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde, methyl acetoacetate and ethyl 3-aminocrotonate was developed. Operational simplicity, mild reaction conditions and eco-friendliness are the key features of this protocol.

引用

页码：21 / 25

页数：4

共 31 条

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