Application of Enzymatic Promiscuity in Pharmaceutical Synthesis: Papain-catalyzed One-pot Synthesis of 1,4-Dihydropyridine Calcium Channel Antagonists and Derivatives

被引：0
作者：
Ling Jiang
Wenting Ye
Weike Su
Chuanming Yu
机构：
[1] Zhejiang University of Technology,Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals
[2] Zhejiang University of Technology,Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences
来源：
Chemical Research in Chinese Universities | 2019年 / 35卷
关键词：
Papain; Catalytic promiscuity; Multicomponent reaction; 1,4-Dihydropyridine calcium channel antagonist;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP) calcium channel antagonists felodipine, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde, methyl acetoacetate and ethyl 3-aminocrotonate was developed. Operational simplicity, mild reaction conditions and eco-friendliness are the key features of this protocol.
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页码：21 / 25
页数：4
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