Dual-time-point FDG PET/CT: Is It Useful for Lymph Node Staging in Patients with Non-Small-Cell Lung Cancer?

被引：12

作者：

Kim D.-W. ^{[1
]}

Kim W.H. ^{[1
]}

Kim C.G. ^{[1
]}

机构：

[1] Department of Nuclear Medicine and Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Jeollabuk-do 570-711

来源：

Nuclear Medicine and Molecular Imaging | 2012年 / 46卷 / 3期

基金：

新加坡国家研究基金会;

关键词：

Dual-time-point imaging; Fluorodeoxyglucose; Lymph node staging; Non-small-cell lung cancer; Positron emission tomography;

D O I：

10.1007/s13139-012-0141-0

中图分类号：

学科分类号：

摘要：

Purpose: Dual-time-point (DTP) FDG PET/CT has been shown to be useful for lymph node (LN) staging in patients with non-small-cell lung cancer (NSCLC). The aim of this study was to evaluate the LN staging ability of DTP FDG PET/CT in the predominant area of pulmonary tuberculosis. Methods: Sixty-nine NSCLC patients underwent DTP PET/CT. Regions of interest were placed on each LN of each station, and the maximum SUVs were measured. Three variables were obtained: (1) the SUV on the early scan (SUV early), (2) the SUV on the delayed scan (SUV delayed), and (3) the retention index of the SUV (RI). Each patient had one final LN stage and three other LN stages according to the cutoff values of SUV early, SUV delayed, and RI. Results: In the LN-based analysis, the area under the ROC curve of SUV delayed (0. 884) was significantly larger (P < 0. 01) than those of SUV early (0. 868) and RI (0. 717). Among the three variables, SUV delayed was more accurate (P < 0. 01) for detecting the mediastinal LN metastasis than SUV early and RI. In the patient-based analysis, SUV delayed had correctly determined LN stages in 55 of 69 patients (sensitivity, specificity, and accuracy = 88. 7 %, 50. 0 %, and 79. 7 %), whereas SUV early and RI correctly determined LN stages in 53 and 52 patients, respectively. Conclusions: In this study, comparing the diagnostic efficacy of SUV early, SUV delayed, and RI for LN staging in patients with NSCLC, SUV delayed was the most accurate variable for LN staging. DTP PET/CT could provide improved diagnostic accuracy for the LN staging of NSCLC. © 2012 Korean Society of Nuclear Medicine.

引用

页码：196 / 200

页数：4

共 16 条

[1]

Mountain C.F., Revisions in the International System for Staging Lung Cancer, Chest, 111, pp. 1710-1717, (1997)

[2]

Gupta N.C., Tamim W.J., Graeber G.G., Bishop H.A., Hobbs G.R., Mediastinal lymph node sampling following positron emission tomography with fluorodeoxyglucose imaging in lung cancer staging, Chest, 120, pp. 521-527, (2001)

[3]

Konishi J., Yamazaki K., Tsukamoto E., Tamaki N., Onodera Y., Otake T., Et al., Mediastinal lymph node staging by FDG-PET in patients with non-small cell lung cancer: analysis of false-positive FDG-PET findings, Respiration, 70, pp. 500-506, (2003)

[4]

Takamochi K., Yoshida J., Murakami K., Niho S., Ishii G., Nishimura M., Et al., Pitfalls in lymph node staging with positron emission tomography in non-small cell lung cancer patients, Lung Cancer, 47, pp. 235-242, (2005)

[5]

Kubota R., Kubota K., Yamada S., Tada M., Ido T., Tamahashi N., Microautoradiographic study for the differentiation of intratumoral macrophages, granulation tissues and cancer cells by the dynamics of fluorine-18-fluorodeoxyglucose uptake, J Nucl Med, 35, pp. 104-112, (1994)

[6]

Nishiyama Y., Yamamoto Y., Kimura N., Ishikawa S., Sasakawa Y., Ohkawa M., Dual-time-point FDG-PET for evaluation of lymph node metastasis in patients with non-small-cell lung cancer, Ann Nucl Med, 22, pp. 245-250, (2008)

[7]

Shinya T., Rai K., Okumura Y., Fujiwara K., Matsuo K., Yonei T., Et al., Dual-time-point F-18 FDG PET/CT for evaluation of intrathoracic lymph nodes in patients with non-small cell lung cancer, Clin Nucl Med, 34, pp. 216-221, (2009)

[8]

Uesaka D., Demura Y., Ishizaki T., Ameshima S., Miyamori I., Sasaki M., Et al., Evaluation of dual-time-point 18F-FDG PET for staging in patients with lung cancer, J Nucl Med, 49, pp. 1606-1612, (2008)

[9]

Kasai T., Motoori K., Horikoshi T., Uchiyama K., Yasufuku K., Takiguchi Y., Et al., Dual-time point scanning of integrated FDG PET/CT for the evaluation of mediastinal and hilar lymph nodes in non-small cell lung cancer diagnosed as operable by contrast-enhanced CT, Eur J Radiol, 75, pp. 143-146, (2010)

[10]

Suga K., Kawakami Y., Hiyama A., Sugi K., Okabe K., Matsumoto T., Et al., Differential diagnosis between (18)F-FDG-avid metastatic lymph nodes in non-small cell lung cancer and benign nodes on dual-time point PET/CT scan, Ann Nucl Med, 23, pp. 523-531, (2009)

← 1 2 →