Are elderly and women under-represented in cardiovascular clinical trials? Implication for treatment

[1] Appelman Y(2015)Sex differences in cardiovascular risk factors and disease prevention Atherosclerosis 241 211-218

[2] van Rijn BB(2009)Gender differences in the cardiovascular effect of sex hormones Nat Rev Cardiol 6 532-542

[3] Ten Haaf ME(1991)The Yentl syndrome N Engl J Med 325 274-276

[4] Boersma E(2015)Gender differences in the effect of cardiovascular drugs: a position document of the Working Group on Pharmacology and Drug Therapy of the ESC Eur Heart J 36 2677-2680

[5] Peters SA(2002)The 2030 problem: caring for aging baby boomers Health Serv Res 37 849-884

[6] Vitale C(2005)Cardiovascular drug therapy in elderly patients: specific age-related pharmacokinetic, pharmacodynamic and therapeutic considerations Drugs Aging 22 913-941

[7] Mendelsohn ME(2000)Users’ Guides to the Medical Literature: XXV. Evidence-based medicine: principles for applying the Users’ Guides to patient care. Evidence-Based Medicine Working Group JAMA 284 1290-1296

[8] Rosano GM(1999)Threats to applicability of randomised trials: exclusions and selective participation J Health Serv Res Policy 4 112-121

[9] Healy B(2002)To whom do the research findings apply? Heart 87 570-574

[10] Rosano GM(2000)Evaluation of large scale clinical trials and their application to usual practice Heart 84 679-684

[1] Appelman Y(2015)Sex differences in cardiovascular risk factors and disease prevention Atherosclerosis 241 211-218

[2] van Rijn BB(2009)Gender differences in the cardiovascular effect of sex hormones Nat Rev Cardiol 6 532-542

[3] Ten Haaf ME(1991)The Yentl syndrome N Engl J Med 325 274-276

[4] Boersma E(2015)Gender differences in the effect of cardiovascular drugs: a position document of the Working Group on Pharmacology and Drug Therapy of the ESC Eur Heart J 36 2677-2680

[5] Peters SA(2002)The 2030 problem: caring for aging baby boomers Health Serv Res 37 849-884

[6] Vitale C(2005)Cardiovascular drug therapy in elderly patients: specific age-related pharmacokinetic, pharmacodynamic and therapeutic considerations Drugs Aging 22 913-941

[7] Mendelsohn ME(2000)Users’ Guides to the Medical Literature: XXV. Evidence-based medicine: principles for applying the Users’ Guides to patient care. Evidence-Based Medicine Working Group JAMA 284 1290-1296

[8] Rosano GM(1999)Threats to applicability of randomised trials: exclusions and selective participation J Health Serv Res Policy 4 112-121

[9] Healy B(2002)To whom do the research findings apply? Heart 87 570-574

[10] Rosano GM(2000)Evaluation of large scale clinical trials and their application to usual practice Heart 84 679-684