Effect of peptide Lys-Glu on interleukin-2 gene expression in lymphocytes

被引：2

作者：

V. Kh. Khavinson

V. G. Morozov

V. V. Malinin

T. B. Kazakova

E. A. Korneva

机构：

[1] Northwestern Division of the Russian Academy of Medical Sciences,Institute of Biologicla Regulation and Gerontology

[2] Russian Academy of Medical Sciences,Department of General Pathology and Pathophysiology, Institute of Experimental Medicine

来源：

Bulletin of Experimental Biology and Medicine | 2000年 / 130卷 / 3期

关键词：

D O I：

10.1007/BF02682264

中图分类号：

学科分类号：

摘要：

Lys-Gluin vitro stimulated interleukin-2 gene expression in mouse spleen lymphocytes. This effect depended on peptide concentration, and duration of treatment. It is hypothesized that this peptide is the shortest regulatory fragment promoting the transport of trans-acting factors into the nucleus. It can not be excluded that Lys-Glu is a structural component of transacting factor active centers, which are necessary for the activation of interleukin-2 gene transcription in lymphocytes.

引用

页码：898 / 899

页数：1

共 24 条

[1]

Aprikyan V. S.(1998)undefined Neirokhimiya 15 189-194

[2]

Galoyan K. A.(1996)undefined Neirokhimiya 13 90-97

[3]

Grishina T. V.(1996)undefined Byull. Eksp. Biol. Med. 122 334-337

[4]

Myul'berg A. A.(1993)undefined Eksp. Klin. Farmakol. 56 51-51

[5]

Golovko O. I.(1996)undefined Cytokine 8 658-666

[6]

Kazakova T. B.(1994)undefined Mol. Cell. Biol. 14 2159-2169

[7]

Burov S. V.(1995)undefined Neuroimmunomodulation 2 290-298

[8]

Golovko O. I.(1999)undefined Cancer Immunol. Immunother. 48 312-320

[9]

Cheido M. A.(undefined)undefined undefined undefined undefined-undefined

[10]

Idova G. V.(undefined)undefined undefined undefined undefined-undefined

← 1 2 3 →