Renal cell cancer correlated with occupational exposure to trichloroethene

被引：0

作者：

S. Vamvakas

T. Brüning

B. Thomasson

M. Lammert

A. Baumüller

H. M. Bolt

W. Dekant

G. Birner

D. Henschler

K. Ulm

机构：

[1] Institute of Toxicology,

[2] University of Würzburg,undefined

[3] Versbacher Str. 9,undefined

[4] D-97078 Würzburg,undefined

[5] Germany,undefined

[6] Department of Work Physiology,undefined

[7] University of Dortmund,undefined

[8] Ardeystr. 67,undefined

[9] D-44139 Dortmund,undefined

[10] Germany,undefined

[11] Institute of Medical Statistics and Epidemiology,undefined

[12] Technical University München,undefined

[13] Ismaninger Str. 22,undefined

[14] D-81675 München,undefined

[15] Germany,undefined

[16] Am Stötchen 17,undefined

[17] D-58219 Arnsberg,undefined

[18] Germany,undefined

[19] Department of Urology,undefined

[20] Karolinen-Hospital,undefined

[21] Stolte-Ley Nr. 5,undefined

[22] D-59759 Arnsberg,undefined

[23] Germany,undefined

来源：

Journal of Cancer Research and Clinical Oncology | 1998年 / 124卷

关键词：

Key words Trichloroethene; Occupational exposure; Renal cell tumors; Epidemiology;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A previous cohort-study in a cardboard factory demonstrated that high and prolonged occupational exposure to trichloroethene (C2HCl3) is associated with an increased incidence of renal cell cancer. The present hospital-based case/control study investigates occupational exposure in 58 patients with renal cell cancer with special emphasis on C2HCl3 and the structurally and toxicologically closely related compound tetrachloroethene (C2Cl4). A group of 84 patients from the accident wards of three general hospitals in the same area served as controls. Of the 58 cases, 19 had histories of occupational C2HCl3 exposure for at least 2 years and none had been exposed to C2Cl4; of the 84 controls, 5 had been occupationally exposed to C2HCl3 and 2 to C2Cl4. After adjustment for other risk factors, such as age, obesity, high blood pressure, smoking and chronic intake of diuretics, the study demonstrates an association of renal cell cancer with long-term exposure to C2HCl3 (odds ratio 10.80; 95% CI: 3.36–34.75).

引用

页码：374 / 382

页数：8