Meiotic spindle assembly checkpoint and aneuploidy in males versus females

被引：0
作者：
Simon Lane
Liisa Kauppi
机构：
[1] University of Southampton,Department of Chemistry and the Institute for Life Sciences
[2] University of Helsinki,Faculty of Medicine
来源：
Cellular and Molecular Life Sciences | 2019年 / 76卷
关键词：
Meiosis; Oocyte; Spermatocytes; Chromosome segregation; Aneuploidy; Recombination; Cohesin; Chiasma; Crossover;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The production of gametes (sperm and eggs in mammals) involves two sequential cell divisions, meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to different daughter cells, and meiosis II resembles mitotic divisions in that sister chromatids separate. While in principle the process is identical in males and females, the time frame and susceptibility to chromosomal defects, including achiasmy and cohesion weakening, and the response to mis-segregating chromosomes are not. In this review, we compare and contrast meiotic spindle assembly checkpoint function and aneuploidy in the two sexes.
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页码：1135 / 1150
页数：15
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