Mini review: linkage between α-Synuclein protein and cognition

被引：0
作者：
Huda Saleh
Ayeh Saleh
Hailan Yao
Jie Cui
Yong Shen
Rena Li
机构：
[1] Center for Advanced Therapeutic Strategies for Brain Disorders Roskamp Institute,Center for Hormone Advanced Science and Education
[2] Roskamp Institute,Neurodegenerative Disease Research Center, School of Life Sciences
[3] University of Science and Technology of China,Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital
[4] Beijing Institute for Brain Disorders,undefined
[5] Capital Medical University,undefined
来源：
Translational Neurodegeneration | / 4卷
关键词：
α-Synuclein; Parkinson’s disease; Cognition; Memory; Learning; Alzheimer’s disease;
D O I：
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学科分类号：
摘要：
α-synuclein is a protein that plays important roles in cognitive function in the normal brain, although its exact role is not fully understood. However, current studies reveal that defects in α-synuclein function could contribute to various neurodegenerative disorders, such as Parkinson’s disease (PD), a disease with symptomatic progression of deterioration in motor and cognitive function. Recent studies show that the level of α -synuclein in cerebrospinal fluid (CSF) is highly correlated with speed of cognitive decline, suggesting a potential role of α-synuclein in cognitive function. In this mini review, we will be focus on literatures of α-synuclein in cognitive function in the non-diseased brain, as well as the impact that defective α-synuclein has on cognition in disease brain. This will be accomplished by assessing the effects of soluble α-synuclein, α-synuclein oligomers, and extracellular α-synuclein transport, on neurodegeneration.
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