Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

被引：0
作者：
Anna Cebula
Michal Seweryn
Grzegorz A. Rempala
Simarjot Singh Pabla
Richard A. McIndoe
Timothy L. Denning
Lynn Bry
Piotr Kraj
Pawel Kisielow
Leszek Ignatowicz
机构：
[1] Center for Biotechnology and Genomic Medicine,Department of Pediatrics
[2] Georgia Regents University,Department of Pathology
[3] Mathematical Biosciences Institute,Department of Tumor Immunology
[4] College of Public Health,undefined
[5] Ohio State University,undefined
[6] Faculty of Mathematics and Computer Science,undefined
[7] University of Lodz,undefined
[8] Emory University,undefined
[9] Brigham and Women's Hospital,undefined
[10] Harvard Medical School,undefined
[11] Ludwik Hirszfeld Institute of Immunology and Experimental Therapy,undefined
来源：
Nature | 2013年 / 497卷
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摘要：
By using high-throughput sequencing of T-cell receptors, this study shows that thymus-derived regulatory T (Treg) cells constitute most Treg cells in all lymphoid and intestinal organs, including the colon, suggesting that thymic Treg cells and not induced Treg cells dominantly control tolerance to the gut’s antigens such as commensal microbiota.
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页码：258 / 262
页数：4
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