Monocyte chemoattractant protein-1 and the blood–brain barrier

被引：0
|
作者：
Yao Yao
Stella E. Tsirka
机构：
[1] Stony Brook University,Program in Molecular and Cellular Pharmacology, Department of Pharmacological Sciences, BST8
[2] The Rockefeller University,192
来源：
Cellular and Molecular Life Sciences | 2014年 / 71卷
关键词：
MCP1; BBB; BMECs; Pericytes; Astrocytes; BM; Microglia; Neurons;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The blood–brain barrier (BBB) is a dynamic structure that maintains the homeostasis of the brain and thus proper neurological functions. BBB compromise has been found in many pathological conditions, including neuroinflammation. Monocyte chemoattractant protein-1 (MCP1), a chemokine that is transiently and significantly up-regulated during inflammation, is able to disrupt the integrity of BBB and modulate the progression of various diseases, including excitotoxic injury and hemorrhage. In this review, we first introduce the biochemistry and biology of MCP1, and then summarize the effects of MCP1 on BBB integrity as well as individual BBB components.
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页码：683 / 697
页数：14
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