Cortical adrenal mitochondrial morphology changes in functional state: new insights

被引：0
作者：
Raffaella Isola
Paola Solinas
Carolina Concettoni
Francesca Atzeni
Francesco Loy
Martina Diana
Michela Isola
Gilberta Giacchetti
Marco Boscaro
Alessandro Riva
Stefano Mariotti
机构：
[1] University of Cagliari,Department of Biomedical Sciences
[2] Cittadella Universitaria di Monserrato,Department of Clinical Medicine and Applied Biotechnologies
[3] Polytechnic University of Marche,Department of Medical Sciences “M. Aresu”
[4] Policlinico Universitario,Department of Biomedical Science, Section of Cytomorphology
[5] AOU,undefined
[6] Cittadella Universitaria di Monserrato,undefined
来源：
Cell and Tissue Research | 2013年 / 351卷
关键词：
Adrenocorticotrophic hormone; Angiotensin II; Dexamethasone; Adrenal cortex; Mitochondria; High resolution scanning electron microscopy; Rat (Sprague Dawley);
D O I：
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中图分类号：
学科分类号：
摘要：
We compared changes in the morphology of mitochondrial cristae with those in the blood and adrenal content of steroid hormones after the stimulation or inhibition of steroidogenesis. Rats were treated with adrenocorticotrophic hormone or angiotensin II to elicit steroidogenesis and with dexamethasone to inhibit it. Blood and adrenal glands were collected after several time intervals for measurements of steroids and their main intermediates. In the zona fasciculata, mitochondrial ultrastructure was investigated by high resolution scanning electron microscopy. We found that the morphometric data correlated well with the measurements of hyper- or hypo-activity of steroidogenesis over short periods of time (4 h) but not over longer observation times. A peculiar finding was that, contrary to previous reports, 11-deoxycortisol was present in adult rat adrenal tissue.
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页码：409 / 417
页数：8
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