Sydnone Sulfonamide Derivatives as Antibacterial, Antifungal, Antiproliferative and Anti-HIV Agents

被引：0
|
作者：
Shahrukh T. Asundaria
Christophe Pannecouque
Erik De Clercq
Keshav C. Patel
机构：
[1] Veer Narmad South Gujarat University,Department of Chemistry
[2] Rega Institute for Medical Research,undefined
[3] K. U. Leuven,undefined
来源：
Pharmaceutical Chemistry Journal | 2014年 / 48卷
关键词：
anti-HIV; antiprolioferative; sydnone; sulfonamides;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Three series of substituted sydnone sulfonamide derivatives were synthesized wherein 3-(4-methylphenyl)-4-(chlorosulfonyl)sydnone (5) was linked by a sulfonamide linkage with various thiazole, benzothiazole and quinazoline groups. The structures of the compounds were confirmed by IR and NMR spectroscopy and elemental analysis. The synthesized compounds were evaluated for their antibacterial, antifungal, antiproliferative and anti-HIV activities. Anti-HIV activity was determined against human immunodeficiency virus HIV-1 (III-B) and HIV-2 (ROD) in MT-4 cells. Inhibition of cytomegalovirus and varicella-zoster virus (VZV) replication was measured in human embryonic lung (HEL) cells.
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页码：260 / 268
页数：8
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