Exploring rapid chemical separations of Sc-47 produced from photonuclear reactions on natural vanadium targets

被引:0
作者
Jessica L. Meiers
Ari Foley
Caitlin Beattie
Mathew S. Snow
机构
[1] Idaho National Laboratory,
[2] Idaho Falls,undefined
来源
Journal of Radioanalytical and Nuclear Chemistry | 2022年 / 331卷
关键词
Sc-47; Rapid chemistry; SPECT; Photonuclear; Scandium-47;
D O I
暂无
中图分类号
学科分类号
摘要
Scandium-47 (47Sc) production via bremsstrahlung irradiation of natural vanadium targets offers significant advantages for producing high purity 47Sc; this work evaluates several rapid dissolution and chemical separation techniques for recovering high purity 47Sc from irradiated vanadium. Techniques developed are combined into a simple, gram-scale, semi-automated target processing system that enables 47Sc recovery from irradiated vanadium targets with chemical yields as high as 93 ± 3% and 47Sc/V separation factors of 6 ± 3 ·1011 within 90 min total processing times. Future research into H2O2 resistant separation techniques and their applicability for direct process coupling to chelation are recommended.
引用
收藏
页码:5623 / 5630
页数:7
相关论文
共 59 条
[1]  
Qaim SM(2018)New developments in the production of theranostic pairs of radionuclides J Radioanal Nucl Chem DOI 100 457-461
[2]  
Scholten B(2019)Therapeutic Potential of Pharm DOI 331 1723-1730
[3]  
Neumaier B(2015)Production, biodistribution, and dosimetry of 4 7 10-tetraazacyclododecane-1 4 7 10-tetramethylene phosphonic acid as a bone-seeking radiopharmaceutical Journal of Medical Physics DOI undefined undefined-undefined
[4]  
Siwowska K(2013)Stability of J Radioanal Nucl Chem DOI undefined undefined-undefined
[5]  
Guzik P(2014)Sc-complexes with acyclic polyamine-polycarboxylate ligand J Nuclear Med DOI undefined undefined-undefined
[6]  
Domnanich K(2018)Promising prospects for Appl Radiat Isot DOI undefined undefined-undefined
[7]  
Rodrigues JMM(1977)Sc-/ reaction Int J Appl Radiation Isot DOI undefined undefined-undefined
[8]  
Bernhardt P(2017)Sc-based theragnostics: application of Radioanal Nucl Chem undefined undefined-undefined
[9]  
Ponsard B(2016)Sc for radionuclide tumor therapy in mice Appl Radiat Isotop DOI undefined undefined-undefined
[10]  
Hasler R(2012)Electron linear accelerator production and purification of 47Sc from titanium dioxide targets Radiochim Acta undefined undefined-undefined