The role of hormonal therapy in breast cancer

被引：1
作者：
Noguchi M. [1 ,2 ]
Miwa K. [2 ]
机构：
[1] Operation Center, Kanazawa University Hospital, School of Medicine, Kanazawa 920, Takara-machi
[2] Department of Surgery (II), Kanazawa University Hospital, School of Medicine
来源：
Breast Cancer | 1998年 / 5卷 / 1期
关键词：
Breast cancer; Hormonal therapy; Randomized trial;
D O I：
10.1007/BF02967413
中图分类号：
学科分类号：
摘要：
This review reassesses the role of hormonal therapy in breast cancer specifically the sequential or concurrent use of endocrine therapy and the combined use of chemotherapy with endocrine therapy. In advanced disease the sequential use of hormone therapies is generally recommended rather than the combined use of various hormonal agents, though combination hormonal therapy offers advantages in certain subsets of patients. The efficacy of combined chemo-endocrine therapy is questionable. Chemotherapy with estrogenic recruitment is an attractive but still experimental concept. However, in an adjuvant setting there is evidence that combined chemo-endocrine therapy causes a significant increase in disease-free and/or overall survival, particularly in postmenopausal patients with estrogen receptor (Expositive tumors. While hormonal treatment strategies have clearly benefitted from randomized studies, data regarding optimal endocrine therapy are still insufficient.
引用
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页码：33 / 46
页数：13
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