The potential of spectral domain optical coherence tomography imaging based retinal biomarkers

被引：48
作者：
Phadikar P. [1 ]
Saxena S. [1 ]
Ruia S. [1 ]
Lai T.Y. [2 ]
Meyer C.H. [3 ]
Eliott D. [4 ]
机构：
[1] Department of Ophthalmology, King George's Medical University, Lucknow, U.P
[2] Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Shatin
[3] Department of Ophthalmology, Pallas Klinik, Aarau
[4] Harvard Medical School, Massachusetts Eye and Ear, Boston, MA
来源：
International Journal of Retina and Vitreous | / 3卷 / 1期
关键词：
Age related macular degeneration; Biomarkers; Diabetic retinopathy; Inherited macular disorder; Optical coherence tomography; Retinitis pigmentosa; Vitreomacular interface disorders;
D O I：
10.1186/s40942-016-0054-7
中图分类号：
学科分类号：
摘要：
Background: Biomarker", a merged word of "biological marker", refers to a broad subcategory of medical signs that objectively indicate the state of health, and well-being of an individual. Biomarkers hold great promise for personalized medicine as information gained from diagnostic or progression markers can be used to tailor treatment to the individual for highly effective intervention in the disease process. Optical coherence tomography (OCT) has proved useful in identifying various biomarkers in ocular and systemic diseases. Main body: Spectral domain optical coherence tomography imaging-based biomarkers provide a valuable tool for detecting the earlier stages of the disease, tracking progression, and monitoring treatment response. The aim of this review article is to analyze various OCT based imaging biomarkers and their potential to be considered as surrogate endpoints for diabetic retinopathy, age related macular degeneration, retinitis pigmentosa and vitreomacular interface disorder. These OCT based surrogate markers have been classified as retinal structural alterations (macular central subfield thickness and cube average thickness); retinal ultrastructural alterations (disruption of external limiting membrane and ellipsoid zone, thinning of retinal nerve fiber layer and ganglion cell layer); intraretinal microangiopathic changes; choroidal surrogate endpoints; and vitreoretinal interface endpoints. Conclusion: OCT technology is changing very quickly and throughout this review there are some of the multiple possibilities that OCT based imaging biomarkers will be more useful in the near future for diagnosis, prognosticating disease progression and as endpoint in clinical trials. © The Author(s) 2017.
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[11]  
Sun J.K., Lin M.M., Lammer J., Prager S., Sarangi R., Silva P.S., Aiello L.P., Disorganization of the retinal inner layers as a predictor of visual acuity in eyes with center-involved diabetic macular edema, JAMA Ophthalmol, 132, pp. 1309-1316, (2014)
[12]  
Sharma S., Saxena S., Srivastav K., Shukla R.K., Mishra N., Meyer C.H., Kruzliak P., Khanna V.K., Nitric oxide and oxidative stress is associated with severity of diabetic retinopathy and retinal structural alterations, Clin Exp Ophthalmol, 43, pp. 429-436, (2015)
[13]  
Jain A., Saxena S., Khanna V.K., Shukla R.K., Meyer C.H., Status of serum VEGF and ICAM-1 and its association with external limiting membrane and inner segment-outer segment junction disruption in type 2 diabetes mellitus, Mol Vis, 19, pp. 1760-1768, (2013)
[14]  
Saxena S., Ruia S., Prasad S., Jain A., Mishra N., Natu S.M., Meyer C.H., Gilhotra J.S., Kruzliak P., Akduman L., Increased serum levels of urea and creatinine are surrogate markers for disruption of retinal photoreceptor external limiting membrane and inner segment ellipsoid zone in type 2 diabetes mellitus, (2016)
[15]  
Oshitari T., Hanawa K., Adachi-Usami E., Changes of macular and RNFL thicknesses measured by Stratus OCT in patients with early stage diabetes, Eye, 23, pp. 884-889, (2009)
[16]  
Srivastav K., Saxena S., Mahdi A.A., Kruzliak P., Khanna V.K., Increased serum urea and creatinine levels correlate with decreased retinal nerve fibre layer thickness in diabetic retinopathy, Biomarkers, 20, pp. 470-473, (2015)
[17]  
Srivastav K., Saxena S., Ruia S., Mahdi A.A., Khanna V.K., Correlation of retinal nerve fibre layer thinning and central subfield thickness with type 2 diabetic retinopathy on spectral domain optical coherence tomography, Open Sci J Clin Med, 3, pp. 194-198, (2015)
[18]  
Rodrigues E.B., Urias M.G., Penha F.M., Badaro E., Novais E., Meirelles R., Farah M.E., Diabetes induces changes in neuroretina before retinal vessels: a spectral-domain optical coherence tomography study, Int J Retina Vitreous, 1, (2015)
[19]  
Uji A., Murakami T., Unoki N., Ogino K., Horii T., Yoshitake S., Dodo Y., Yoshimura N., Parallelism for quantitative image analysis of photoreceptor-retinal pigment epithelium complex alterations in diabetic macular EdemaParallelism in DME, Invest Ophthalmol Vis Sci, 55, pp. 3361-3367, (2014)
[20]  
Branchini L.A., Regatieri C., Carmody J., Fujimoto J.G., Duker J.S., Choroidal thickness in patients with diabetic retinopathy analyzed by spectral domain optical coherence tomography, Invest Ophthalmol Vis Sci, 52, (2011)
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