The potential of spectral domain optical coherence tomography imaging based retinal biomarkers

被引：48
作者：
Phadikar P. [1 ]
Saxena S. [1 ]
Ruia S. [1 ]
Lai T.Y. [2 ]
Meyer C.H. [3 ]
Eliott D. [4 ]
机构：
[1] Department of Ophthalmology, King George's Medical University, Lucknow, U.P
[2] Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Shatin
[3] Department of Ophthalmology, Pallas Klinik, Aarau
[4] Harvard Medical School, Massachusetts Eye and Ear, Boston, MA
来源：
International Journal of Retina and Vitreous | / 3卷 / 1期
关键词：
Age related macular degeneration; Biomarkers; Diabetic retinopathy; Inherited macular disorder; Optical coherence tomography; Retinitis pigmentosa; Vitreomacular interface disorders;
D O I：
10.1186/s40942-016-0054-7
中图分类号：
学科分类号：
摘要：
Background: Biomarker", a merged word of "biological marker", refers to a broad subcategory of medical signs that objectively indicate the state of health, and well-being of an individual. Biomarkers hold great promise for personalized medicine as information gained from diagnostic or progression markers can be used to tailor treatment to the individual for highly effective intervention in the disease process. Optical coherence tomography (OCT) has proved useful in identifying various biomarkers in ocular and systemic diseases. Main body: Spectral domain optical coherence tomography imaging-based biomarkers provide a valuable tool for detecting the earlier stages of the disease, tracking progression, and monitoring treatment response. The aim of this review article is to analyze various OCT based imaging biomarkers and their potential to be considered as surrogate endpoints for diabetic retinopathy, age related macular degeneration, retinitis pigmentosa and vitreomacular interface disorder. These OCT based surrogate markers have been classified as retinal structural alterations (macular central subfield thickness and cube average thickness); retinal ultrastructural alterations (disruption of external limiting membrane and ellipsoid zone, thinning of retinal nerve fiber layer and ganglion cell layer); intraretinal microangiopathic changes; choroidal surrogate endpoints; and vitreoretinal interface endpoints. Conclusion: OCT technology is changing very quickly and throughout this review there are some of the multiple possibilities that OCT based imaging biomarkers will be more useful in the near future for diagnosis, prognosticating disease progression and as endpoint in clinical trials. © The Author(s) 2017.
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共 76 条
[1]  
Strimbu K., Tavel J.A., What are biomarkers?, Curr Opin HIV AIDS, 5, pp. 463-466, (2010)
[2]  
Downing G.J., Biomarkers and surrogate endpoints: clinical research and applications, Proceedings of the NIH-FDA conference held on 15-16 April 1999 in Bethesda, (2000)
[3]  
Aronson J.K., Biomarkers and surrogate endpoints, Br J Clin Pharmacol, 59, pp. 491-494, (2005)
[4]  
Hill A.B., The environment and disease: association or causation?, Proc R Soc Med, 58, (1965)
[5]  
Buyse M., Sargent D.J., Grothey A., Matheson A., De Gramont A., Biomarkers and surrogate end points-the challenge of statistical validation, Nat Rev Clin Oncol, 7, pp. 309-317, (2010)
[6]  
Ruia S., Saxena S., Targeted screening of macular edema by spectral domain optical coherence tomography for progression of diabetic retinopathy, Indian Journal of Ocular Biology, 1, (2016)
[7]  
Browning D.J., Glassman A.R., Aiello L.P., Beck R.W., Brown D.M., Relationship between optical coherence tomography-measured central retinal thickness and visual acuity in diabetic macular edema, Ophthalmology, 114, pp. 525-536, (2007)
[8]  
Pelosini L., Hull C.C., Boyce J.F., McHugh D., Stanford M.R., Marshall J., Optical coherence tomography may be used to predict visual acuity in patients with macular edema, Invest Ophthalmol Vis Sci, 52, pp. 2741-2748, (2011)
[9]  
Alkuraya H., Kangave D., El-Asrar A.M., The correlation between optical coherence tomographic features and severity of retinopathy, macular thickness and visual acuity in diabetic macular edema, Int Ophthalmol, 26, pp. 93-99, (2005)
[10]  
Ruia S., Saxena S., Prasad S., Sharma S.R., Akduman L., Khanna V.K., Correlation of biomarkers thiobarbituric acid reactive substance, nitric oxide and central subfield and cube average thickness in diabetic retinopathy: a cross-sectional study, Int J Retina Vitreous, 2, (2016)
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