MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

被引：0
作者：
Karthik Mallilankaraman
César Cárdenas
Patrick J. Doonan
Harish C. Chandramoorthy
Krishna M. Irrinki
Tünde Golenár
György Csordás
Priyanka Madireddi
Jun Yang
Marioly Müller
Russell Miller
Jill E. Kolesar
Jordi Molgó
Brett Kaufman
György Hajnóczky
J. Kevin Foskett
Muniswamy Madesh
机构：
[1] Temple University,Department of Biochemistry
[2] University of Pennsylvania,Department of Physiology
[3] Anatomy,Department of Pathology
[4] and Cell Biology,Department of Animal Biology
[5] Thomas Jefferson University,Department of Cell and Developmental Biology
[6] Institute for Diabetes,undefined
[7] Obesity and Metabolism,undefined
[8] University of Pennsylvania,undefined
[9] University of Pennsylvania School of Veterinary Medicine,undefined
[10] CNRS,undefined
[11] Institut de Neurobiologie Alfred Fessard,undefined
[12] FRC2118,undefined
[13] Laboratoire de Neurobiologie et Développement,undefined
[14] UPR 3294,undefined
[15] Center for Translational Medicine,undefined
[16] Temple University,undefined
[17] University of Pennsylvania,undefined
来源：
Nature Cell Biology | 2012年 / 14卷
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学科分类号：
摘要：
The mitochondrial calcium uniporter (MCU) mediates calcium uptake by mitochondria and thus regulates cellular bioenergetics, but how MCU activity is modulated is not fully understood. Madesh, Foskett and colleagues report that the integral mitochondrial membrane protein MCUR1 (mitochondrial calcium uniporter regulator 1) binds to the MCU and promotes MCU-dependent calcium uptake to control ATP production and autophagy.
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页码：1336 / 1343
页数：7
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