MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

被引：0

作者：

Karthik Mallilankaraman

César Cárdenas

Patrick J. Doonan

Harish C. Chandramoorthy

Krishna M. Irrinki

Tünde Golenár

György Csordás

Priyanka Madireddi

Jun Yang

Marioly Müller

Russell Miller

Jill E. Kolesar

Jordi Molgó

Brett Kaufman

György Hajnóczky

J. Kevin Foskett

Muniswamy Madesh

机构：

[1] Temple University,Department of Biochemistry

[2] University of Pennsylvania,Department of Physiology

[3] Anatomy,Department of Pathology

[4] and Cell Biology,Department of Animal Biology

[5] Thomas Jefferson University,Department of Cell and Developmental Biology

[6] Institute for Diabetes,undefined

[7] Obesity and Metabolism,undefined

[8] University of Pennsylvania,undefined

[9] University of Pennsylvania School of Veterinary Medicine,undefined

[10] CNRS,undefined

[11] Institut de Neurobiologie Alfred Fessard,undefined

[12] FRC2118,undefined

[13] Laboratoire de Neurobiologie et Développement,undefined

[14] UPR 3294,undefined

[15] Center for Translational Medicine,undefined

[16] Temple University,undefined

[17] University of Pennsylvania,undefined

来源：

Nature Cell Biology | 2012年 / 14卷

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学科分类号：

摘要：

The mitochondrial calcium uniporter (MCU) mediates calcium uptake by mitochondria and thus regulates cellular bioenergetics, but how MCU activity is modulated is not fully understood. Madesh, Foskett and colleagues report that the integral mitochondrial membrane protein MCUR1 (mitochondrial calcium uniporter regulator 1) binds to the MCU and promotes MCU-dependent calcium uptake to control ATP production and autophagy.

引用

页码：1336 / 1343

页数：7

共 50 条

[1] MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism
Mallilankaraman, Karthik
Cardenas, Cesar
Doonan, Patrick J.
Chandramoorthy, Harish C.
Irrinki, Krishna M.
Golenar, Tuende
Csordas, Gyoergy
Madireddi, Priyanka
Yang, Jun
Mueller, Marioly
Miller, Russell
Kolesar, Jill E.
Molgo, Jordi
Kaufman, Brett
Hajnoczky, Gyoergy
Foskett, J. Kevin
Madesh, Muniswamy
NATURE CELL BIOLOGY, 2012, 14 (12) : 1336 - +
[2] MCUR1 is an Essential Component of Mitochondrial Ca2+ Uptake that regulates Cellular Metabolism
Mallilankaraman, Karthik
Cardenas, Cesar
Doonan, Patrick
Chandramoorthy, Harish
Irrinki, Krishna
Golenar, Tunde
Csordas, Gyorgy
Madireddi, Priyanka
Yang, Jun
Miller, Russell
Koesar, Jill
Kaufman, Brett
Hajnoczky, Gyorgy
Foskett, Kevin James
Madesh, Muniswamy
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[3] Erratum: MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism
Karthik Mallilankaraman
César Cárdenas
Patrick J. Doonan
Harish C. Chandramoorthy
Krishna M. Irrinki
Tünde Golenár
György Csordás
Priyanka Madireddi
Jun Yang
Marioly Müller
Russell Miller
Jill E. Kolesar
Jordi Molgó
Brett Kaufman
György Hajnóczky
J. Kevin Foskett
Muniswamy Madesh
Nature Cell Biology, 2013, 15 : 123 - 123
[4] Correction: Corrigenda: MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism
Karthik Mallilankaraman
César Cárdenas
Patrick J. Doonan
Harish C. Chandramoorthy
Krishna M. Irrinki
Tünde Golenár
György Csordás
Priyanka Madireddi
Jun Yang
Marioly Müller
Russell Miller
Jill E. Kolesar
Jordi Molgó
Brett Kaufman
György Hajnóczky
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Nature Cell Biology, 2015, 17 : 953 - 953
[5] MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism (vol 14, pg 1336, 2012)
Mallilankaraman, Karthik
Cardenas, Cesar
Doonan, Patrick J.
Chandramoorthy, Harish C.
Irrinki, Krishna M.
Golenar, Tuende
Csordas, Gyoergy
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Yang, Jun
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Foskett, J. Kevin
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NATURE CELL BIOLOGY, 2013, 15 (01) : 123 - 123
[6] MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism (vol 14, pg 1336, 2012)
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Yang, Jun
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[8] Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism
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[10] Mitochondrial morphology regulates organellar Ca2+ uptake and changes cellular Ca2+ homeostasis
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