Analysis of Drug/Plasma Protein Interactions by Means of Asymmetrical Flow Field-Flow Fractionation

被引：0
作者：
Maya Madörin
Peter van Hoogevest
Rolf Hilfiker
Birgit Langwost
Gerhard M. Kresbach
Markus Ehrat
Hans Leuenberger
机构：
[1] Novartis Pharma AG,Pharmaceutical and Analytical Development
[2] CH-,School of Pharmacy
[3] University of Basel,BioAnalytical Research
[4] Novartis Pharma AG,School of Pharmacy
[5] CH-4002 Basel,undefined
[6] University of Basel,undefined
来源：
Pharmaceutical Research | 1997年 / 14卷
关键词：
asymmetrical flow field-flow fractionation; FFF; plasma proteins; HAS; lipoproteins; N-Benzoyl-staurosporine; recovery; separation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The applicability of Asymmetrical Flow Field-Flow Fractionation (Asymmetrical Flow FFF) as an alternative tool to examine the distribution of a lipophilic drug (N-Benzoyl-staurosporine) within human plasma protein fractions was investigated with respect to high separation speed and loss of material on surfaces due to adsorption.
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页码：1706 / 1712
页数：6
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