Negative regulation of TGF-β signaling in development

被引：0
作者：
Ye Guang CHEN
An Ming MENG
机构：
[1] The State Key Laboratory of Biomembrane and Membrane Biotechnology,Department of Biological Sciences and Biotechnology
[2] Tsinghua University,undefined
来源：
Cell Research | 2004年 / 14卷
关键词：
TGF-β; BMP; Nodal; Activin; antagonist; development; negative regulation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The TGF-β superfamily members have important roles in controlling patterning and tissue formation in both invertebrates and vertebrates. Two types of signal transducers, receptors and Smads, mediate the signaling to regulate expression of their target genes. Despite of the relatively simple signal transduction pathway, many modulators have been found to contribute to a tight regulation of this pathway in a variety of mechanisms. This article reviews the negative regulation of TGF-β signaling with focus on its roles in vertebrate development.
引用
收藏
页码：441 / 449
页数：8
相关论文
共 292 条
  • [1] Shi Y(2003)Mechanisms of TGF-beta signaling from cell membrane to the nucleus Cell 113 685-700
  • [2] Massague J(2000)TGFb signaling in growth control, cancer, and heritable disorders Cell 103 295-309
  • [3] Massague J(2000)Controlling TGF-b signaling Genes Dev 14 627-44
  • [4] Blain SW(2003)Smad-dependent and Smad-independent pathways in TGF-beta family signalling Nature 425 577-84
  • [5] Lo RS(2000)Regulation of Smad activity Cell 100 189-92
  • [6] Massague J(2004)Dorsal-ventral patterning and neural induction in Annu Rev Cell Dev Biol 20 285-308
  • [7] Chen YG(2003) embryos Annu Rev Cell Dev Biol 19 589-621
  • [8] Derynck R(1998)Nodal signaling in vertebrate development Genes Dev 12 2445-62
  • [9] Zhang YE(1999)Smads and early developmental signaling by the TGFbeta superfamily Nature 398 427-31
  • [10] Wrana JL(2002)Local inhibition and long-range enhancement of Dpp signal transduction by Sog Nature 419 304-8
12345678910