Erythrocyte rheological properties but not whole blood and plasma viscosity are associated with severity of hypertension in older people; [Zusammenhang des Hypertonieschweregrads bei älteren Menschen mit den rheologischen Eigenschaften der Erythrozyten, nicht aber mit der Viskosität von Vollblut und Plasma]

被引：0

作者：

Fu G.-X. ^{[1
]}

Ji M. ^{[1
]}

Han L.-Z. ^{[1
]}

Xu C.-C. ^{[1
]}

Pan F.-F. ^{[1
]}

Hu T.-J. ^{[1
]}

Zhong Y. ^{[1
]}

机构：

[1] Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, No. 600, Yi Shan Road, Shanghai

来源：

Zeitschrift für Gerontologie und Geriatrie | 2017年 / 50卷 / 3期

关键词：

Aged; Blood pressure; Blood viscosity; Erythrocyte deformability; Vascular resistance;

D O I：

10.1007/s00391-016-1039-8

中图分类号：

学科分类号：

摘要：

Objective: This study was carried out to determine whether changes in hemorheological parameters parallel the severity of essential hypertension. Methods: A total of 198 older hypertensive patients were recruited and classified into 3 stages of hypertension according to the grading standard of hypertension. The whole blood viscosity (WBV) at various shear rates, plasma viscosity and erythrocyte rheology (including erythrocyte rigidity index, erythrocyte aggregation index and erythrocyte deformation index) were examined. Results: Erythrocyte rheology paralleled the severity of essential hypertension and was significantly correlated to the average 24 h systolic blood pressure and diastolic blood pressure. Logistic analysis revealed that erythrocyte rigidity and the erythrocyte aggregation index were positively correlated with the severity of hypertension, while the erythrocyte deformation index was negatively correlated. No association was found between WBV, plasma viscosity and the severity of hypertension. Conclusion: The rheological properties of erythrocyte viscosity were correlated with the severity of hypertension in older people but the WBV and plasma viscosity were not. © 2016, Springer-Verlag Berlin Heidelberg.

引用

页码：233 / 238

页数：5

共 34 条

[1]

Stuart J., Kenny M.W., Blood rheology, J Clin Pathol, 3, pp. 417-429, (1980)

[2]

Chien S., Blood rheology in hypertension and cardiovascular disease, Cardiovasc Med, 2, pp. 356-360, (1977)

[3]

Yapislar H., Taskin E., L-carnosine alters some hemorheologic and lipid peroxidation parameters in nephrectomized rats, Med Sci Monit, 11, 20, pp. 399-405, (2014)

[4]

Bhavsar J., Rosenson R.S., Adenosine transport, erythrocyte deformability and microvascular dysfunction: an unrecognized potential role for dipyridamole therapy, Clin Hemorheol Microcirc, 44, pp. 193-205, (2010)

[5]

Jae S.Y., Kurl S., Laukkanen J.A., Et al., Higher blood hematocrit predicts hypertension in men, J Hypertens, 32, pp. 245-250, (2014)

[6]

Letcher R.L., Chien S., Pickering T.G., Sealey J.E., Laragh J.H., Direct relationship between blood pressure and blood viscosity in normal and hypertensive subjects. Role of fibrinogen and concentration, Am J Med, 70, pp. 1195-1202, (1981)

[7]

Fowkes F.G., Lowe G.D., Rumley A., Lennie S.E., Smith F.B., Donnan P.T., The relationship between blood viscosity and blood pressure in a random sample of the population aged 55 to 74 years, Eur Heart J, 14, pp. 597-601, (1993)

[8]

Carallo C., Irace C., De Franceschi M.S., Et al., The effect of aging on blood plasma viscosity. An 11.6 years follow-up study, Clin Hemorheol Microcirc, 47, pp. 67-74, (2011)

[9]

Pickering T.G., Hall J.E., Appel L.J., Et al., Recommendations for blood pressure measurement in humans and experimental animals: Part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research, Hypertension, 45, pp. 142-161, (2005)

[10]

Baskurt O.K., Boynard M., Cokelet G.C., Et al., New guidelines for hemorheological laboratory techniques, Clin Hemorheol Microcirc, 42, pp. 75-97, (2009)

← 1 2 3 4 →