CYP46A1 and the APOEε4 Allele Polymorphisms Correlate with the Risk of Alzheimer’s Disease

被引：0
作者：
Ling Li
Fan Zeng
Yu-Hui Liu
Hui-Yun Li
Shu-Yang Dong
Ze-Yan Peng
Yan-Jiang Wang
Hua-Dong Zhou
机构：
[1] Third Military Medical University,Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital and Research Institute of Surgery
[2] Bengbu Medical College,Postgraduate School
来源：
Molecular Neurobiology | 2018年 / 55卷
关键词：
Cholesterol 24S-hydroxylase gene (; ); Apolipoprotein E (; ); Alzheimer’s disease (AD); 24S-hydroxcholesterol (24-OHC); Amyloid-beta (Aβ);
D O I：
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摘要：
Polymorphisms of the cholesterol-24S-hydroxylase (CYP46A1) and apolipoprotein E (APOE) genes are risk factors for Alzheimer’s disease (AD). Plasma level of 24S-hydroxcholesterol (24-OHC), the metabolite of cholesterol, is thought to correlate with AD. The present study investigated the correlation between these genetic factors and blood 24-OHC and amyloid-beta (Aβ) levels in AD patients. Association analysis, logistic regression, and linear regression were used to analyze the correlation of CYP46A1 and APOE genotypes with blood 24-OHC and Aβ levels and AD risk. We found that the APOEε4 alleles were significantly higher in patients with AD and there was a potential synergistic interaction between the CYP46A1 C allele and APOEε4 allele in AD. Blood 24-OHC level and Aβ level were significantly higher in AD patients than controls, indicating 24-OHC could be a marker in AD diagnosis. However, AD patients with the CYP46A1 TT, but not CC, genotype had higher 24-OHC levels, which indicated that there may be other mechanisms in the relationship between CYP46A1 polymorphisms and AD.
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页码：8179 / 8187
页数：8
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