MicroRNAs as biomarkers and perspectives in the therapy of pancreatic cancer

被引：0
作者：
Tao Xia
Xiao-Yi Chen
You-Ni Zhang
机构：
[1] Zhejiang Provincial People’s Hospital,Department of Gastrointestinal
[2] Affiliated Hospital of Hangzhou Medical College,Pancreatic Surgery, General Surgery
[3] Zhejiang Provincial People’s Hospital,Key Laboratory of Gastroenterology of Zhejiang Province
[4] Affiliated Hospital of Hangzhou Medical College,Clinical Research Institute
[5] Zhejiang Provincial People’s Hospital,Department of Laboratory Medicine
[6] Affiliated Hospital of Hangzhou Medical College,undefined
[7] Tiantai People’s Hospital of Zhejiang Province (Tiantai Branch of Zhejiang People’s Hospital),undefined
来源：
Molecular and Cellular Biochemistry | 2021年 / 476卷
关键词：
Pancreatic cancer; miRNA; Cancer therapy; Cancer prognosis; Cancer diagnosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Pancreatic cancer is considered as one of the most aggressive tumor types, representing over 45,750 mortality cases annually in the USA solely. The aggressive nature and late identification of pancreatic cancer, combined with the restrictions of existing chemotherapeutics, present the mandatory need for the advancement of novel treatment systems. Ongoing reports have shown an important role of microRNAs (miRNAs) in the initiation, migration, and metastasis of malignancies. Besides, abnormal transcriptional levels of miRNAs have regularly been related with etiopathogenesis of pancreatic malignancy, underlining the conceivable utilization of miRNAs in the management of pancreatic disease patients. In this review article, we give a concise outline of molecular pathways involved in etiopathogenesis of pancreatic cancer patients as well as miRNA implications in pancreatic cancer patients. Ensuing sections describe the involvement of miRNAs in the diagnosis, prognosis, and therapy of pancreatic cancer patients. The involvement of miRNAs in the chemoresistance of pancreatic cancers was also discussed. End area portrays the substance of survey with future headings.
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页码：4191 / 4203
页数：12
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