Multiple rectal carcinoids with diffuse ganglioneuromatosis

被引:21
作者
Haraguchi M. [1 ,4 ]
Kinoshita H. [2 ]
Koori M. [1 ]
Tsuneoka N. [1 ]
Kosaka T. [1 ]
Ito Y. [3 ]
Furui J. [1 ]
Kanematsu T. [4 ]
机构
[1] Department of Surgery, Goto Central Hospital, Nagasaki
[2] Department of Internal Medicine, Goto Central Hospital, Nagasaki
[3] Department of Pathology, SRL Nishi-nihon
[4] Department of Surgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki
关键词
Carcinoid Tumor; Multiple Endocrine Neoplasia; Rectal Carcinoid; Ganglioneuromas; Rectal Carcinoid Tumor;
D O I
10.1186/1477-7819-5-19
中图分类号
学科分类号
摘要
Background: Rectal carcinoids comprise only about 1% of all anorectal neoplasms. In addition, ganglioneuroma of the gastrointestinal tract is a rare tumor composed ganglion cells, nerve fibers, and supporting cells. Multiple carcinoid tumors with diffuse ganglioneuromatosis limited to the rectum are quite unusual. Case presentation: A 69-year-old man was referred to us because of about 100 small submucosal rectal tumors. He underwent abdominoperineal resection. Pathology revealed carcinoid tumors for about 30 submucosal nodules and diffuse ganglioneuromotosis. To date (6 months later) he remains well with no recurrence. Conclusion: Although the optimal treatment for the multiple rectal carcinoids remains to be clearly established, it is believed that not all patients with multiple rectal carcinoids (measuring less than 1 cm in diameter) need to have a radical operation. However, the treatment plan for each case should be individualized and a careful follow-up is mandatory. © 2007 Haraguchi et al; licensee BioMed Central Ltd.
引用
收藏
相关论文
共 8 条
[1]  
Winburn G.B., Multiple rectal carcinoids: A case report, Am Surg, 64, pp. 1200-1203, (1998)
[2]  
Sumida T., Nagata S., Ougoshi H., Ishida Y., Kuwahara T., Tatsugami M., Tsuji K., Hidaka T., Tachiyama Y., Kaneko M., Hayashi Y., Multiple rectal carcinoid tumors treated by endoscopic mucosal resection-Report of a case, Gastroenterol Endosc, 47, pp. 1419-1424, (2005)
[3]  
Rafiq S., Hameer H., Sitrin M.D., Ganglioneuromatous polyposis associated with juvenile polyps and a tubular adenoma, Dig Dis Sci, 50, pp. 506-508, (2005)
[4]  
Kanter A.S., Hyman N.H., Li S.C., Ganglioneuromatous polyposis: A premalignant condition. Report of a case and review of the literature, Dis Colon Rectum, 44, pp. 591-593, (2001)
[5]  
Jetmore A.B., Ray J.E., Gathright Jr. J.B., McMullen K.M., Hicks T.C., Timmcke A.E., Rectal carcinoids: The most frequent carcinoid tumor, Dis Colon Rectum, 35, pp. 717-725, (1992)
[6]  
Maruyama M., Fukayama M., Koike M., A case of multiple carcinoid tumors of the rectum with extraglandular endocrine cell proliferation, Cancer, 61, pp. 131-136, (1988)
[7]  
Katdare M.V., Fichera A., Heimann T.M., Familial rectal carcinoid: Report of two first-degree relatives with rectal carcinoid and review of the literature, Tech Coloproctol, 10, pp. 143-146, (2006)
[8]  
Hansen O.P., Hansen M., Hansen H.H., Rose B., Multiple endocrine adenomatosis of mixed type, Acta Med Scand, 200, pp. 327-331, (1976)