Delayed-onset enzootic bovine leukosis possibly caused by superinfection with bovine leukemia virus mutated in the pol gene

被引：0
作者：
Tadaaki Watanabe
Emi Inoue
Hiroshi Mori
Yoshiaki Osawa
Katsunori Okazaki
机构：
[1] Health Sciences University of Hokkaido,Laboratory of Microbiology and Immunology, Faculty of Pharmaceutical Sciences
来源：
Archives of Virology | 2015年 / 160卷
关键词：
Long Terminal Repeat; Bovine Leukemia Virus; Moloney Murine Leukemia Virus Reverse Transcriptase; Defective Virus; Enzootic Bovine Leukosis;
D O I：
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中图分类号：
学科分类号：
摘要：
Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis (EBL), to which animals are most susceptible at 4–8 years of age. In this study, we examined tumor cells associated with EBL in an 18-year-old cow to reveal that the cells carried at least two different copies of the virus, one of which was predicted to encode a reverse transcriptase (RT) lacking ribonuclease H activity and no integrase. Such a deficient enzyme may exhibit a dominant negative effect on the wild-type RT and cause insufficient viral replication, resulting in delayed tumor development in this cow.
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页码：2087 / 2091
页数：4
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