Pathogenesis of neonatal necrotizing enterocolitis

被引：0
作者：
Joanna C. Lim
Jamie M. Golden
Henri R. Ford
机构：
[1] Children’s Hospital Los Angeles,Division of Pediatric Surgery
[2] Keck School of Medicine of the University of Southern California,Department of Surgery
来源：
Pediatric Surgery International | 2015年 / 31卷
关键词：
Necrotizing enterocolitis; Pediatric surgery; Neonatal intensive care unit; Pathophysiology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Although necrotizing enterocolitis (NEC) is the most lethal gastrointestinal disease in the neonatal population, its pathogenesis is poorly understood. Risk factors include prematurity, bacterial colonization, and formula feeding. This review examines how mucosal injury permits opportunistic pathogens to breach the gut barrier and incite an inflammatory response that leads to sustained overproduction of mediators such as nitric oxide and its potent adduct, peroxynitrite. These mediators not only exacerbate the initial mucosal injury, but they also suppress the intestinal repair mechanisms, which further compromises the gut barrier and culminates in bacterial translocation, sepsis, and full-blown NEC.
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页码：509 / 518
页数：9
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