Diffuse microdamage in bone activates anabolic response by osteoblasts via involvement of voltage-gated calcium channels

[1] Gupta HS(2008)Fracture of bone tissue: the ‘hows’ and the ‘whys’ Med Eng Phys 30 1209-1226

[2] Zioupos P(1960)Presence of microscopic cracks in vivo in bone Henry Ford Hosp Med Bull 8 35-629

[3] Frost H(2005)Micro- and nano-structural analyses of damage in bone Micron 36 617-861

[4] Sahar ND(2015)Bone microdamage, remodeling and bone fragility: how much damage is too much damage? Bonekey Rep 4 644-274

[5] Hong SI(2008)In vivo linear microcracks of human femoral cortical bone remain parallel to osteons during aging Bone 43 856-345

[6] Kohn DH(1977)Compact bone fatigue damage: a microscopic examination Clin Orthop Relat Res 127 265-1303

[7] Seref-Ferlengez Z(1998)Does microdamage accumulation affect the mechanical properties of bone? J Biomech 31 337-605

[8] Kennedy OD(2004)Do microcracks decrease or increase fatigue resistance in cortical bone? J Biomech 37 1295-268

[9] Schaffler MB(2009)Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue J Bone Miner Res 24 597-446

[10] Wasserman N(2007)Living with cracks: damage and repair in human bone Nat Mater 6 263-772

[1] Gupta HS(2008)Fracture of bone tissue: the ‘hows’ and the ‘whys’ Med Eng Phys 30 1209-1226

[2] Zioupos P(1960)Presence of microscopic cracks in vivo in bone Henry Ford Hosp Med Bull 8 35-629

[3] Frost H(2005)Micro- and nano-structural analyses of damage in bone Micron 36 617-861

[4] Sahar ND(2015)Bone microdamage, remodeling and bone fragility: how much damage is too much damage? Bonekey Rep 4 644-274

[5] Hong SI(2008)In vivo linear microcracks of human femoral cortical bone remain parallel to osteons during aging Bone 43 856-345

[6] Kohn DH(1977)Compact bone fatigue damage: a microscopic examination Clin Orthop Relat Res 127 265-1303

[7] Seref-Ferlengez Z(1998)Does microdamage accumulation affect the mechanical properties of bone? J Biomech 31 337-605

[8] Kennedy OD(2004)Do microcracks decrease or increase fatigue resistance in cortical bone? J Biomech 37 1295-268

[9] Schaffler MB(2009)Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue J Bone Miner Res 24 597-446

[10] Wasserman N(2007)Living with cracks: damage and repair in human bone Nat Mater 6 263-772