Levels of Soluble CD40 Ligand and P-Selectin in Nonalcoholic Fatty Liver Disease

被引：0
作者：
Cemal Nuri Ercin
Teoman Dogru
Serkan Tapan
Yıldırım Karslioglu
Cem Haymana
Selim Kilic
Alper Sonmez
Zeki Yesilova
Ahmet Uygun
Mustafa Gulsen
Sait Bagci
M. Kemal Erbil
机构：
[1] Gulhane School of Medicine,Department of Gastroenterology
[2] Gulhane School of Medicine,Department of Biochemistry
[3] Gulhane School of Medicine,Department of Pathology
[4] Gulhane School of Medicine,Department of Internal Medicine
[5] Gulhane School of Medicine,Department of Epidemiology
[6] Gulhane School of Medicine,Department of Endocrinology
来源：
Digestive Diseases and Sciences | 2010年 / 55卷
关键词：
Soluble CD40 ligand; Soluble P-selectin; NAFLD; Atherosclerosis;
D O I：
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学科分类号：
摘要：
Nonalcoholic fatty liver disease (NAFLD) is linked to an increased risk of cardiovascular disease. We aimed to research whether the levels of soluble P-selectin (sP-selectin) and soluble CD40 ligand (sCD40L), markers of endothelial function, are altered in subjects with NAFLD having no confounding factors for atherosclerosis. sCD40L, sP-selectin, and high-sensitivity C-reactive protein (hsCRP) levels, and homeostasis model assessment of insulin resistance (HOMA-IR) indexes were measured in 50 NAFLD subjects and 30 healthy controls. sCD40L, sP-selectin, and hsCRP levels were not significantly different between two groups (P = 0.48, 0.51, and 0.34, respectively). Body mass index, waist circumference, and insulin levels and HOMA indexes were significantly higher in subjects with NAFLD (all P < 0.001). The present data show that sCD40L and sP-selectin may not contribute to the accelerated atherogenesis associated with this clinically relevant condition.
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页码：1128 / 1134
页数：6
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