SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1

被引:0
作者
Sin-Yee Fung
Kam-Leung Siu
Huayue Lin
Ching-Ping Chan
Man Lung Yeung
Dong-Yan Jin
机构
[1] The University of Hong Kong,School of Biomedical Sciences
[2] Hong Kong Science and Technology Park,Centre for Virology, Vaccinology and Therapeutics
[3] The University of Hong Kong,Department of Microbiology
[4] The University of Hong Kong,State Key Laboratory of Emerging Infectious Diseases
[5] The University of Hong Kong-Shenzhen Hospital,Department of Clinical Microbiology and Infection Control
来源
Cell & Bioscience | / 12卷
关键词
SARS-CoV-2; COVID-19; NSP13; Helicase; JAK1; STAT1;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
[41]   In silico analysis of altered expression of long non-coding RNA in SARS-CoV-2 infected cells and their possible regulation by STAT1, STAT3 and interferon regulatory factors [J].
Laha, Sayantan ;
Saha, Chinmay ;
Dutta, Susmita ;
Basu, Madhurima ;
Chatterjee, Raghunath ;
Ghosh, Sujoy ;
Bhattacharyya, Nitai P. .
HELIYON, 2021, 7 (03)
[42]   TNF-α/IFN-γ synergy amplifies senescence-associated inflammation and SARS-CoV-2 receptor expression via hyper-activated JAK/STAT1 [J].
Kandhaya-Pillai, Renuka ;
Yang, Xiaomeng ;
Tchkonia, Tamar ;
Martin, George M. ;
Kirkland, James L. ;
Oshima, Junko .
AGING CELL, 2022, 21 (06)
[43]   Screening of FDA-approved compound library identifies potential small-molecule inhibitors of SARS-CoV-2 non-structural proteins NSP1, NSP4, NSP6 and NSP13: molecular modeling and molecular dynamics studies [J].
Shobana Sundar ;
Lokesh Thangamani ;
Shanmughavel Piramanayagam ;
Chandrasekar Narayanan Rahul ;
Natarajan Aiswarya ;
Kanagaraj Sekar ;
Jeyakumar Natarajan .
Journal of Proteins and Proteomics, 2021, 12 (3) :161-175
[44]   Artesunate induces substantial topological alterations in the SARS-CoV-2 Nsp1 protein structure [J].
Gurung, Arun Bahadur ;
Ali, Mohammad Ajmal ;
Lee, Joongku ;
Abul Farah, Mohammad ;
Al-Anazi, Khalid Mashay ;
Al-Hemaid, Fahad .
JOURNAL OF KING SAUD UNIVERSITY SCIENCE, 2022, 34 (02)
[45]   Novel mutations in NSP-1 and PLPro of SARS-CoV-2 NIB-1 genome mount for effective therapeutics [J].
Mohammad Uzzal Hossain ;
Arittra Bhattacharjee ;
Md. Tabassum Hossain Emon ;
Zeshan Mahmud Chowdhury ;
Ishtiaque Ahammad ;
Md. Golam Mosaib ;
Md. Moniruzzaman ;
Md. Hadisur Rahman ;
Md. Nazrul Islam ;
Irfan Ahmed ;
Md. Ruhul Amin ;
Asif Rashed ;
Keshob Chandra Das ;
Chaman Ara Keya ;
Md. Salimullah .
Journal of Genetic Engineering and Biotechnology, 19
[46]   The NSP6-L260F substitution in SARS-CoV-2 BQ.1.1 and XBB.1.16 lineages compensates for the reduced viral polymerase activity caused by mutations in NSP13 and NSP14 [J].
Furusawa, Yuri ;
Iwatsuki-Horimoto, Kiyoko ;
Yamayoshi, Seiya ;
Kawaoka, Yoshihiro .
JOURNAL OF VIROLOGY, 2025,
[47]   Novel mutations in NSP-1 and PLPro of SARS-CoV-2 NIB-1 genome mount for effective therapeutics [J].
Hossain, Mohammad Uzzal ;
Bhattacharjee, Arittra ;
Emon, Md. Tabassum Hossain ;
Chowdhury, Zeshan Mahmud ;
Ahammad, Ishtiaque ;
Mosaib, Md. Golam ;
Moniruzzaman, Md. ;
Rahman, Md. Hadisur ;
Islam, Md. Nazrul ;
Ahmed, Irfan ;
Amin, Md. Ruhul ;
Rashed, Asif ;
Das, Keshob Chandra ;
Keya, Chaman Ara ;
Salimullah, Md. .
JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY, 2021, 19 (01)
[48]   Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 Spike Protein Subunit 1 [J].
Cory, Theodore J. ;
Emmons, Russell S. ;
Yarbro, Johnathan R. ;
Davis, Kierstin L. ;
Pence, Brandt D. .
FRONTIERS IN IMMUNOLOGY, 2021, 12
[49]   JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling [J].
Grant, Alice H. ;
Rodriguez, Alejandro C. ;
Moncivais, Omar J. Rodriguez J. ;
Sun, Shengjie ;
Li, Lin ;
Mohl, Jonathon E. ;
Leung, Ming-Ying ;
Kirken, Robert A. ;
Rodriguez, Georgialina .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (07)
[50]   1H, 13C and 15N backbone chemical shift assignments of SARS-CoV-2 nsp3a [J].
Nicola Salvi ;
Luiza Mamigonian Bessa ;
Serafima Guseva ;
Aldo Camacho-Zarco ;
Damien Maurin ;
Laura Marino Perez ;
Anas Malki ;
Martin Hengesbach ;
Sophie Marianne Korn ;
Andreas Schlundt ;
Harald Schwalbe ;
Martin Blackledge .
Biomolecular NMR Assignments, 2021, 15 :173-176