Design and analysis of a dual-core PCF biosensor based on SPR for cancerous cells detection

被引：7
作者：
Majeed, Mohammed F. [1 ,2 ]
Ahmad, Ahmad K. [3 ]
机构：
[1] Al Nahrain Univ, Coll Sci, Dept Phys, POB 64055, Baghdad, Iraq
[2] Baghdad Univ, Remote Sensing Unit, Baghdad, Iraq
[3] Al Nahrain Univ, Coll Engn, Dept Laser & Optoelect Engn, POB 64044, Baghdad, Iraq
来源：
OPTICAL AND QUANTUM ELECTRONICS | 2024年 / 56卷 / 06期
关键词：
Cancer cell detection; Surface plasmon resonance; Photonic crystal fiber; Biosensor; Plasmonic materials; Refractometric sensor; PHOTONIC CRYSTAL FIBER; REFRACTIVE-INDEX SENSOR;
D O I：
10.1007/s11082-024-06566-6
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
The present investigation examines a novel dual-core photonic crystal fiber (PCF) for early cancer cell detection that is based on a surface plasmon resonance (SPR) biosensor. The PCF is coated with Au/TiO2 layers to boost sensor effectiveness by enhancing the adhesion between the fiber and gold layers. The sensor was simulated and analyzed using the COMSOL Multiphysics software, which is based on the finite element method (FEM). Spectral and amplitude interrogations were used to explore the RI fluctuations of various cancer cells. The observed RI values varied within the range of 1.36-1.401. The biosensor's highest sensitivity was found to be 11,429 nm/RIU for MCF-7 cells using spectral interrogation and 1251.18 RIU-1 for MDA-MB231 cells utilizing amplitude interrogation techniques. Additionally, the sensor shows the maximum resolution for basal cells, which is 8.75 x 10-6 RIU.
引用
收藏
页数：19
相关论文
共 40 条
  • [1] Abdelghaffar M., 2022, 2022 International Conference on Numerical Simulation of Optoelectronic Devices (NUSOD), P147, DOI 10.1109/NUSOD54938.2022.9894779
  • [2] Atakaramians S., 2011, Terahertz waveguides: a study of microwires and porous fibres
  • [3] Photonic Crystal Fiber-Based Refractive Index Sensor for Early Detection of Cancer
    Ayyanar, N.
    Raja, G. Thavasi
    Sharma, Mohit
    Kumar, D. Sriram
    [J]. IEEE SENSORS JOURNAL, 2018, 18 (17) : 7093 - 7099
  • [4] Bise R.T., 2005, P OFC NFOEC TECHN DI, P6, DOI DOI 10.1109/OFC.2005.192772
  • [5] Significantly enhanced Birefringence of photonic crystal fiber using rotational binary unit cell in fiber cladding
    Chau, Yuan-Fong
    Yeh, Han-Hsuan
    Tsai, Din Ping
    [J]. JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS & EXPRESS LETTERS, 2007, 46 (41-44): : L1048 - L1051
  • [6] Circulating Tumor DNA: Measurement and Clinical Utility
    Donaldson, Joshua
    Park, Ben Ho
    [J]. ANNUAL REVIEW OF MEDICINE, VOL 69, 2018, 69 : 223 - 234
  • [7] 3D-printed extrusion dies: a versatile approach to optical material processing
    Ebendorff-Heidepriem, Heike
    Schuppich, Juliane
    Dowler, Alastair
    Lima-Marques, Luis
    Monro, Tanya M.
    [J]. OPTICAL MATERIALS EXPRESS, 2014, 4 (08): : 1494 - 1504
  • [8] Cancer statistics for the year 2020: An overview
    Ferlay, Jacques
    Colombet, Murielle
    Soerjomataram, Isabelle
    Parkin, Donald M.
    Pineros, Marion
    Znaor, Ariana
    Bray, Freddie
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2021, 149 (04) : 778 - 789
  • [9] A novel freeform extrusion fabrication process for producing solid ceramic components with uniform layered radiation drying
    Ghazanfari, Amir
    Li, Wenbin
    Leu, Ming C.
    Hillmas, Gregory E.
    [J]. ADDITIVE MANUFACTURING, 2017, 15 : 102 - 112
  • [10] Microchannel-based plasmonic refractive index sensor for low refractive index detection
    Haque, Emranul
    Hossain, Md Anwar
    Namihira, Yoshinori
    Ahmed, Feroz
    [J]. APPLIED OPTICS, 2019, 58 (06) : 1547 - 1554
1234