Anti-adipogenic effects in 3T3-L1 cells of acetone extracts and fractions from Styrax japonica fruit

被引：0
作者：
Jin Kyu Kim
Hajin Nam
Yoo Yeon Kim
Harry Jung
Yoon Soo Choi
Joa Sub Oh
Su Kyoung Chun
Jun Gyo Suh
机构：
[1] Gyeonggi Institute of Science and Technology Promotion,Institute of Natural Medicine
[2] Hallym University,Department of Medical Genetics, College of Medicine
[3] Hallym University,College of Pharmacy
[4] Dankook University,College of Forest & Environmental Sciences
[5] Kangwon National University,undefined
来源：
Food Science and Biotechnology | 2015年 / 24卷
关键词：
adipogenesis; obesity; ROS;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Reduction in reactive oxygen species (ROS) production facilitated by Styrax japonica (SJ) extracts and fractions for inhibition of obesity development through inhibition of adipogenesis was investigated. Treatment of cells with SJ extracts and fractions did not result in changes in cell viability. SJ extracts and fractions inhibited lipid accumulation in a dose-dependent manner during adipogenesis. Expressions of PPARγ and C/EBPα, key adipogenic markers, were decreased in cells treated with SJ extracts and fractions. Inhibitory effects of SJ extracts and fractions were the most powerful in the early stages of differentiation (days 0-2). Intracellular ROS production was decreased in cells treated with SJ extracts and fractions. SJ extracts and fractions can inhibit adipogenesis via reduced ROS levels, which involves down-regulation of adipogenic transcription factors.
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页码：1513 / 1521
页数：8
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