MPEG-b-poly(amino urethane) amphiphilic block copolymers and their pH-Dependent micellization behavior

The MPEG-PAU block coplymers were successfully synthesized and their chemical structures were well characterized by1H,13C NMR and FT-IR spectroscopies. The aqueous solution properties of the copolymers were evaluated by acid-base titration, fluorescence spectroscopy and dynamic light scattering. The block copolymers exhibited a pHdependent micellization-demicellization transition in aqueous solution. The fluorescence spectroscopy and DLS measurements indicate that the micellization-demicellization transition occurs at pH 6.0–6.6. The amphiphilic block copolymers are expected to find applications in biomedical field.