Mice with miR-146a deficiency develop severe gouty arthritis via dysregulation of TRAF 6, IRAK 1 and NALP3 inflammasome

被引:0
作者
Quan-Bo Zhang
Yu-Feng Qing
Cong-Cong Yin
Li Zhou
Xian-shuang Liu
Qing-Sheng Mi
Jing-Guo Zhou
机构
[1] Affiliated Hospital of North Sichuan Medical College,Department of Geriatrics
[2] Henry Ford Health System,Henry Ford Immunology Program, Department of Dermatology and Internal Medicine
[3] Affiliated Hospital,Department of Rheumatology and Immunology
[4] North Sichuan Medical College,Department of Internal Medicine
[5] Affiliated Hospital of Qingdao University,Department of Neurology
[6] Henry Ford Health System,undefined
来源
Arthritis Research & Therapy | / 20卷
关键词
miR-146a; Gout; TRAF6; IRAK1; NALP3 inflammasome;
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[1]  
Lee HE(2016)Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout Sci Rep 6 38622-2052
[2]  
Yang G(2016)Gout Lancet 388 2039-12486
[3]  
Kim ND(2014)MicroRNAs: new regulators of Toll-like receptor signalling pathways Biomed Res Int 2014 945169-84
[4]  
Jeong S(2017)Potential roles of exosomal MicroRNAs as diagnostic biomarkers and therapeutic application in Alzheimer's disease Neural Plast 2017 7027380-1201
[5]  
Jung Y(2006)NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses Proc Natl Acad Sci U S A 103 12481-790
[6]  
Choi JY(2017)MicroRNA-146a governs fibroblast activation and joint pathology in arthritis J Autoimmun 82 74-1940
[7]  
Park HH(2011)miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice J Exp Med 208 1189-3144
[8]  
Lee JY(2015)Role of miR-146a in regulation of the acute inflammatory response to monosodium urate crystals Ann Rheum Dis 74 786-2841
[9]  
Dalbeth N(2014)MiR-146a negatively regulates TLR2-induced inflammatory responses in keratinocytes J Invest Dermatol 134 1931-241
[10]  
Merriman TR(2010)How interleukin-1beta induces gouty arthritis Arthritis Rheum 62 3140-undefined