Multicenter Phase II study of FOLFOX or biweekly XELOX and Erbitux (cetuximab) as first-line therapy in patients with wild-type KRAS/BRAF metastatic colorectal cancer: The FLEET study

被引:0
作者
Hitoshi Soda
Hiromichi Maeda
Junichi Hasegawa
Takao Takahashi
Shoichi Hazama
Mutsumi Fukunaga
Emiko Kono
Masahito Kotaka
Junichi Sakamoto
Naoki Nagata
Koji Oba
Hideyuki Mishima
机构
[1] Showa University Fujigaoka Hospital,Department of Surgery
[2] Kochi Medical School Hospital,Cancer Treatment Center
[3] Kochi University,Department of Surgical Oncology
[4] Osaka Rosai Hospital,Department of Digestive Surgery and Surgical Oncology
[5] Gifu University Hospital,Department of Biostatistics, School of Public Health, Graduate School of Medicine
[6] Yamaguchi University,undefined
[7] Graduate School of Medicine,undefined
[8] Sakai City Hospital,undefined
[9] Japan Community Health care Organization Osaka Hospital,undefined
[10] Sano Hospital,undefined
[11] Tokai Central Hospital,undefined
[12] Kitakyushu General Hospital,undefined
[13] The University of Tokyo,undefined
[14] Aichi Medical University,undefined
来源
BMC Cancer | / 15卷
关键词
Oxaliplatin; Capecitabine; Cetuximab; Metastatic Colorectal Cancer; BRAF Mutation;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 330 条
[1]  
Jonker DJ(2007)Cetuximab for the treatment of colorectal cancer N Engl J Med 357 2040-8
[2]  
O’Callaghan CJ(2011)Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status J Clin Oncol 29 2011-9
[3]  
Karapetis CS(2009)Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer J Clin Oncol 27 663-71
[4]  
Zalcberg JR(2011)Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastaticcolorectal cancer: the OPUS study Ann Oncol 22 1535-46
[5]  
Tu D(2012)Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials Eur J Cancer 48 1466-75
[6]  
Au HJ(2011)Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial Lancet 377 2103-14
[7]  
Berry SR(2009)Toxicity associated with combination oxaliplatin plus fluoropyrimidinewith or without cetuximab in the MRC COIN trial experience Br J Cancer 100 251-8
[8]  
Krahn M(2003)Randomized multicenter phase II trial of two different schedules of capecitabine plus oxaliplatin as first-line treatment in advanced colorectal cancer J Clin Oncol 21 1307-12
[9]  
Price T(2009)Phase II study of biweekly XELOX (capecitabine and oxaliplatin) as first line chemotherapy in elderly patients with metastatic colorectal cancer. 2009 ASCO Annual Meeting J Clin Oncol 27 e15053-45
[10]  
Simes RJ(2010)Cetuximab administered once every second week to patients with metastatic colorectal cancer: a two-part pharmacokinetic/pharmacodynamic phase I dose-escalation study Ann Oncol 21 1537-8