Ocular graft-versus-host disease

被引：6
作者：
Dietrich-Ntoukas, T. [1 ]
Steven, P. [2 ,3 ]
机构：
[1] Charite, Klin Augenheilkunde, D-13353 Berlin, Germany
[2] Univ Cologne, Kompetenzzentrum Okulare GvHD, Zentrum Augenheilkunde, D-50937 Cologne, Germany
[3] Charite, Cellular Stress Responses Aging Associated Dis CE, D-13353 Berlin, Germany
来源：
OPHTHALMOLOGE | 2015年 / 112卷 / 12期
关键词：
Hematopoietic stem cell transplantation; Keratoconjunctivitis sicca; Dry eye disease; Chronic inflammation; Moisturizing disorder; SEVERE DRY EYE; CONSENSUS DEVELOPMENT PROJECT; CLINICAL-TRIALS; DIAGNOSIS; CORNEAL; TRANSPLANTATION; CRITERIA; THERAPY; DROPS;
D O I：
10.1007/s00347-015-0149-9
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Ocular graft-versus-host disease (GvHD) is predominantly an inflammatory ocular surface disorder after allogeneic hematopoietic stem cell transplantation (HSCT) with increasing incidence. It is not only associated with reduced quality of life because of dry eye syndromes but can also impair visual acuity and lead to blindness due to corneal complications. The GvHD is mostly associated with severe moisturizing disorder of the ocular surface, which is often resistant to therapy and accompanied by chronic inflammation. Corneal complications are an important problem in these patients. An individually adapted multimodal stage-related and interdisciplinary therapy in cooperation with hematologists and oncologists is therefore important for the treatment of patients with ocular GvHD.
引用
收藏
页码：1027 / 1038
页数：12
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