Surface Energy of Microcrystalline Cellulose Determined by Capillary Intrusion and Inverse Gas Chromatography

被引：0
作者：
D. Fraser Steele
R. Christian Moreton
John N. Staniforth
Paul M. Young
Michael J. Tobyn
Stephen Edge
机构：
[1] University of Bath,Pharmaceutical Technology Research Group, Department of Pharmacy & Pharmacology
[2] FinnBrit Consulting,Advanced Drug Delivery Group
[3] University of Sydney,Drug Delivery Solutions Ltd
[4] Leatherhead Enterprise Centre,undefined
来源：
The AAPS Journal | 2008年 / 10卷
关键词：
capillary intrusion; dynamic contact angle; excipient; inverse gas chromatography; microcrystalline cellulose; surface energy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Surface energy data for samples of microcrystalline cellulose have been obtained using two techniques: capillary intrusion and inverse gas chromatography. Ten microcrystalline cellulose materials, studied using capillary intrusion, showed significant differences in the measured surface energetics (in terms of total surface energy and the acid–base characteristics of the cellulose surface), with variations noted between the seven different manufacturers who produced the microcrystalline cellulose samples. The surface energy data from capillary intrusion was similar to data obtained using inverse gas chromatography with the column maintained at 44% relative humidity for the three samples of microcrystalline cellulose studied. This suggests that capillary intrusion may be a suitable method to study the surface energy of pharmaceutical samples.
引用
收藏
页码：494 / 503
页数：9
相关论文
共 176 条
  • [51] Gindl W.(1993)Effect of batch variation and source of pulp on the properties of microcrystalline cellulose Int. J. Pharm. 91 133-141
  • [52] Reiterer A.(2000)Inverse gas chromatography investigation of the surface properties of cellulose J. Adhes. Sci. Technol. 14 321-337
  • [53] Tschegg S.(1994)Measurement of the surface free-energy of amorphous cellulose by alkane adsorption—a critical evaluation of inverse gas chromatography (IGC) J. Adhes. 46 165-180
  • [54] Sharma P. K.(1987)Experimentally optimized determination of the partial and total cohesion parameters of an insoluble polymer (Microcrystalline Cellulose) by gas solid chromatography Int. j. pharm. 34 217-223
  • [55] Rao K. H.(1998)Hornification—mechanisms and terminology Paperi ja Puu—Paper and Timber 80 110-115
  • [56] Volpe C. D.(1972)Surface geometry of some microcrystalline celluloses J. Pharm. Pharmacol. Suppl. 24 138P-220
  • [57] Siboni S.(1998)Comparison of the interface between water and four surfaces of native crystalline cellulose by molecular dynamics simulations Carbohydr. Res. 306 205-612
  • [58] Planinšek O.(2003)Chemistry—cellulose stacks up Nature 426 611-77
  • [59] Trojak A.(2002)Interfacial adhesion and microfailure modes of electrodeposited carbon fiber/epoxy–PEI composites by microdroplet and surface wettability tests J. Colloid Interface Sci. 249 62-undefined
  • [60] Srcic S.(undefined)undefined undefined undefined undefined-undefined
12345678910