Surface Energy of Microcrystalline Cellulose Determined by Capillary Intrusion and Inverse Gas Chromatography

被引：0
作者：
D. Fraser Steele
R. Christian Moreton
John N. Staniforth
Paul M. Young
Michael J. Tobyn
Stephen Edge
机构：
[1] University of Bath,Pharmaceutical Technology Research Group, Department of Pharmacy & Pharmacology
[2] FinnBrit Consulting,Advanced Drug Delivery Group
[3] University of Sydney,Drug Delivery Solutions Ltd
[4] Leatherhead Enterprise Centre,undefined
来源：
The AAPS Journal | 2008年 / 10卷
关键词：
capillary intrusion; dynamic contact angle; excipient; inverse gas chromatography; microcrystalline cellulose; surface energy;
D O I：
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中图分类号：
学科分类号：
摘要：
Surface energy data for samples of microcrystalline cellulose have been obtained using two techniques: capillary intrusion and inverse gas chromatography. Ten microcrystalline cellulose materials, studied using capillary intrusion, showed significant differences in the measured surface energetics (in terms of total surface energy and the acid–base characteristics of the cellulose surface), with variations noted between the seven different manufacturers who produced the microcrystalline cellulose samples. The surface energy data from capillary intrusion was similar to data obtained using inverse gas chromatography with the column maintained at 44% relative humidity for the three samples of microcrystalline cellulose studied. This suggests that capillary intrusion may be a suitable method to study the surface energy of pharmaceutical samples.
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页码：494 / 503
页数：9
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