Role of Fungi in the Pathophysiology of Chronic Rhinosinusitis: An Update

被引:0
作者
Kathleen T. Montone
机构
[1] Perelman School of Medicine at the University of Pennsylvania,Division of Surgical Pathology, Department of Pathology and Laboratory Medicine
来源
Current Allergy and Asthma Reports | 2013年 / 13卷
关键词
Chronic rhinosinusitis; Fungi; Allergic fungal rhinosinusitis; Eosinophilic mucin; Th2; Eosinophils; Pathogenesis; Pathophysiology; Antifungal therapy; Treatment;
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摘要
The pathogenesis of chronic rhinosinusitis (CRS) is multi-factorial with an infectious process likely at least partly involved. While bacteria have been proposed to play a critical role in CRS, fungi have also been implicated by some investigators, although the pathogenesis of fungi in CRS represents a significant controversy among rhinologists. Fungal-associated factors believed to be involved in CRS include the ability of fungi to induce significant inflammatory reactions by different means through inducing localized cytokine production in the sinonasal tract. Despite these observations, randomized, controlled studies on CRS patients using antifungal therapy have not resulted in significant improvement in CRS patients. The role of fungi in the pathogenesis of CRS remains controversial.
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页码:224 / 228
页数:4
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