Design and In vitro Investigation of Grafted Chitosan as Chitosan Nanoparticles Containing Deflazacort Drug Coated by Calcium Starch Glycolate

被引：0
作者：
Elsayed M. Abdel Bary
Ammar N. Harmal
Mona E. Ibrahim
Moustafa A. Gouda
机构：
[1] Mansoura University,Department of Chemistry, Faculty of Science
[2] Sa’adah University,Department of Chemistry, Faculty of Science
[3] Taibah University,Department of Chemistry, Faculty of Science and Arts
来源：
Fibers and Polymers | 2020年 / 21卷
关键词：
Chitosan; Mannish base; Chitosan nanoparticles; Deflazacort drug; Drug delivery;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Novel chitosan nanoparticles (SCN) were synthesized via reaction of chitosan with different concentration of 2-chloro-N-(3-methylisoxazol-5-yl) acetamide (5 %, 10 % and 15 %) at 70–80 °C for 7 h to give the grafted polymer, which condensed with cyclohexanone Mannich base 45 °C for 7 h to afford the corresponding (SCN). These were stirred with Deflazacort drug to achieve the Deflazacort loading (SCN), which, compressed with calcium starch glycolate (CaSgly) to give the corresponding tablets. The pH 2. 1 and concentration of SCN-10 %/CaSgly (1:4) was found to be important parameters in controlling the release profiles.
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页码：2718 / 2728
页数：10
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