Impact of tetrachloroethylene-contaminated drinking water on the risk of breast cancer: Using a dose model to assess exposure in a case-control study

被引：21
作者：
Vieira V. [1 ]
Aschengrau A. [2 ]
Ozonoff D. [1 ]
机构：
[1] Department of Environmental Health, Boston Univ. School of Public Health, Boston, MA 02118
[2] Department of Epidemiology, Boston Univ. School of Public Health, Boston, MA 02118
来源：
Environmental Health | / 4卷 / 1期
关键词：
Breast Cancer; Tetrachloroethylene; Dermal Absorption; Dose Model; Public Drinking Water;
D O I：
10.1186/1476-069X-4-3
中图分类号：
学科分类号：
摘要：
Background: A population-based case-control study was undertaken in 1997 to investigate the association between tetrachloroethylene (PCE) exposure from public drinking water and breast cancer among permanent residents of the Cape Cod region of Massachusetts. PCE, a volatile organic chemical, leached from the vinyl lining of certain water distribution pipes into drinking water from the late 1960s through the early 1980s. The measure of exposure in the original study, referred to as the relative delivered dose (RDD), was based on an amount of PCE in the tap water entering the home and estimated with a mathematical model that involved only characteristics of the distribution system. Methods: In the current analysis, we constructed a personal delivered dose (PDD) model that included personal information on tap water consumption and bathing habits so that inhalation, ingestion, and dermal absorption were also considered. We reanalyzed the association between PCE and breast cancer and compared the results to the original RDD analysis of subjects with complete data. Results: The PDD model produced higher adjusted odds ratios than the RDD model for exposures > 50th and >75th percentile when shorter latency periods were considered, and for exposures < 50th and >90th percentile when longer latency periods were considered. Overall, however, the results from the PDD analysis did not differ greatly from the RDD analysis. Conclusion: The inputs that most heavily influenced the PDD model were initial water concentration and duration of exposure. These variables were also included in the RDD model. In this study population, personal factors like bath and shower temperature, bathing frequencies and durations, and water consumption did not differ greatly among subjects, so including this information in the model did not significantly change subjects' exposure classification. © 2005 Vieira et al; licensee BioMed Central Ltd.
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  • [1] Aschengrau A., Ozonoff D., Paulu C., Coogan P., Vezina R., Heeren T., Zhang Y., Cancer risk and tetrachloroethylene-contaminated drinking water in Massachusetts, Arch Environ Health, 48, pp. 284-292, (1993)
  • [2] Aschengrau A., Ozonoff D., Coogan P., Vezina R., Heeren T., Zhang Y., Cancer risk and residential proximity to cranberry cultivation in Massachusetts, Am J Public Health, 86, pp. 1289-1296, (1996)
  • [3] Aschengrau A., Paulu C., Ozonoff D., Tetrachloroethylene-contaminated drinking water and the risk of breast cancer, Environ Health Perspect, 106, pp. 947-953, (1998)
  • [4] Ozonoff D., Aschengrau A., Coogan P., Cancer in the vicinity of a Department of Defense superfund site in Massachusetts, Toxicol Ind Health, 10, pp. 119-141, (1994)
  • [5] Aschengrau A., Rogers S., Ozonoff D., Perchloroethylene-contaminated drinking water and the risk of breast cancer: Additional results from Cape Cod, Massachusetts, USA, Environ Health Perspect, 111, pp. 167-173, (2003)
  • [6] Paulu C., Aschengrau A., Ozonoff D., Tetrachloroethylene-contaminated drinking water and the risk of colon-rectum, lung, and other cancers, Environ Health Perspect, 107, pp. 265-271, (1999)
  • [7] Brody J., Aschengrau A., McKelvey W., Rudel R., Swartz C., Kennedy T., Breast cancer risk and historical exposure to pesticides from wide-area applications assessed with GIS, Environ Health Perspect, 112, pp. 889-897, (2004)
  • [8] Demond A., A Source of Tetrachloroethylene in the Drinking Water of New England: An Evaluation of the Toxicity of Tetrachloroethylene and the Prediction of Its Leaching Rates from Vinyl-lined Asbestos-cement Pipe, (1982)
  • [9] Webler T., Brown H., Exposure to tetrachloroethylene via contaminated drinking water pipes in Massachusetts: A predictive model, Arch Environ Health, 48, pp. 293-297, (1993)
  • [10] McKone T., Human exposure to volatile organic compounds in household tap water: The indoor inhalation pathway, Environ Sci Technol, 21, pp. 1194-1201, (1987)
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