A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using [11C]PK11195

被引：1
|
作者：
Ota M. [1 ]
Ogura J. [1 ]
Ogawa S. [1 ]
Kato K. [2 ,3 ]
Matsuda H. [3 ]
Kunugi H. [1 ]
机构：
[1] Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, 187-8502, Tokyo
[2] Organic Radiochemistry Section, Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National Center Hospital of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, 187-8502, Tokyo
[3] Integrative Brain Imaging Center, National Center Hospital of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, 187-8502, Tokyo
来源：
Nuclear Medicine and Molecular Imaging | 2018年 / 52卷 / 3期
基金：
日本学术振兴会;
关键词：
Glial cells; Lipopolysaccharides; Positron emission tomography; Somatosensory area; [!sup]11[!/sup]C]PK11195;
D O I：
10.1007/s13139-017-0510-9
中图分类号：
学科分类号：
摘要：
Purpose: Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo. Methods: Ten adult male Fischer F344 rats underwent [11C]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [11C]PK11195 between before and after injection was determined. Results: There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas. Conclusions: Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [11C]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [11C]PK11195 PET would clarify the relationships between neuroinflammation and depression. © 2018, Korean Society of Nuclear Medicine.
引用
收藏
页码：224 / 228
页数：4
相关论文
共 50 条
  • [21] Comparison of [11C]-(R)-PK 11195 and [11C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker
    Kreisl, William C.
    Fujita, Masahiro
    Fujimura, Yota
    Kimura, Nobuyo
    Jenko, Kimberly J.
    Kannan, Pavitra
    Hong, Jinsoo
    Morse, Cheryl L.
    Zoghbi, Sami S.
    Gladding, Robert L.
    Jacobson, Steven
    Oh, Unsong
    Pike, Victor W.
    Innis, Robert B.
    NEUROIMAGE, 2010, 49 (04) : 2924 - 2932
  • [22] Changes in GABAA receptor properties in amygdala kindled animals: In vivo studies using [11C]flumazenil and positron emission tomography
    Liefaard, Lia C.
    Ploeger, Bart A.
    Molthoff, Carla F. M.
    de Jong, Hugo W. A. M.
    Dijkstra, Jouke
    van der Weerd, Louise
    Lammertsma, Adriaan A.
    Danhof, Meindert
    Voskuyl, Rob A.
    EPILEPSIA, 2009, 50 (01) : 88 - 98
  • [23] Evaluation of age-related changes in translocator protein (TSPO) in human brain using 11C-[R]-PK11195 PET
    Ajay Kumar
    Otto Muzik
    Varun Shandal
    Diane Chugani
    Pulak Chakraborty
    Harry T Chugani
    Journal of Neuroinflammation, 9
  • [24] Evaluation in rats and primates of [11C]-mecamylamine, a potential nicotinic acetylcholine receptor radioligand for positron emission tomography
    Sobrio, F
    Debruyne, D
    Dhilly, M
    Chazalviel, L
    Camsonne, R
    Kakiuchi, T
    Tsukada, H
    Barré, L
    NEUROCHEMISTRY INTERNATIONAL, 2005, 46 (06) : 479 - 488
  • [25] Neuroinflammation in acute hepatic encephalopathy rats: imaging and therapeutic effectiveness evaluation using 11C-PK11195 and 18F-DPA-714 micro-positron emission tomography
    Song Luo
    Xiang Kong
    Jin Rong Wu
    Chun Yan Wang
    Ying Tian
    Gang Zheng
    Yun Yan Su
    Guang Ming Lu
    Long Jiang Zhang
    Gui Fen Yang
    Metabolic Brain Disease, 2018, 33 : 1733 - 1742
  • [26] Neuroinflammation in acute hepatic encephalopathy rats: imaging and therapeutic effectiveness evaluation using 11C-PK11195 and 18F-DPA-714 micro-positron emission tomography
    Luo, Song
    Kong, Xiang
    Wu, Jin Rong
    Wang, Chun Yan
    Tian, Ying
    Zheng, Gang
    Su, Yun Yan
    Lu, Guang Ming
    Zhang, Long Jiang
    Yang, Gui Fen
    METABOLIC BRAIN DISEASE, 2018, 33 (05) : 1733 - 1742
  • [27] Changes in myocardial oxidative metabolism after biventricular pacing as evaluated by [11C]acetate positron emission tomography
    Tsutomu Araki
    Naohiro Yoshida
    Taketsugu Tsuchiya
    Masatoshi Ikeda
    Masanobu Namura
    Takahiro Higuchi
    Junichi Taki
    Annals of Nuclear Medicine, 2003, 17 : 605 - 608
  • [28] Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography
    Cannon, Dara M.
    Ichise, Masanori
    Fromm, Stephen J.
    Nugent, Allison C.
    Rollis, Denise
    Gandhi, Shilpa K.
    Klaver, Jacqueline M.
    Charney, Dennis S.
    Manji, Husseini K.
    Drevets, Wayne C.
    BIOLOGICAL PSYCHIATRY, 2006, 60 (03) : 207 - 217
  • [29] Quantification of aromatase binding in the female human brain using [11C]cetrozole positron emission tomography
    Jonasson, My
    Nordeman, Patrik
    Eriksson, Jonas
    Wilking, Helena
    Wikstrom, Johan
    Takahashi, Kayo
    Niwa, Takashi
    Hosoya, Takamitsu
    Watanabe, Yasuyoshi
    Antoni, Gunnar
    Sundstrom Poromaa, Inger
    Lubberink, Mark
    Comasco, Erika
    JOURNAL OF NEUROSCIENCE RESEARCH, 2020, 98 (11) : 2208 - 2218
  • [30] Changes in myocardial oxidative metabolism after biventricular pacing as evaluated by [11C]acetate positron emission tomography
    Araki, T
    Yoshida, N
    Tsuchiya, T
    Ikeda, M
    Namura, M
    Higuchi, T
    Taki, J
    ANNALS OF NUCLEAR MEDICINE, 2003, 17 (07) : 605 - 608
12345