A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using [11C]PK11195

被引：1

作者：

Ota M. ^{[1
]}

Ogura J. ^{[1
]}

Ogawa S. ^{[1
]}

Kato K. ^{[2
,3
]}

Matsuda H. ^{[3
]}

Kunugi H. ^{[1
]}

机构：

[1] Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, 187-8502, Tokyo

[2] Organic Radiochemistry Section, Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National Center Hospital of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, 187-8502, Tokyo

[3] Integrative Brain Imaging Center, National Center Hospital of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, 187-8502, Tokyo

来源：

Nuclear Medicine and Molecular Imaging | 2018年 / 52卷 / 3期

基金：

日本学术振兴会;

关键词：

Glial cells; Lipopolysaccharides; Positron emission tomography; Somatosensory area; [!sup]11[!/sup]C]PK11195;

D O I：

10.1007/s13139-017-0510-9

中图分类号：

学科分类号：

摘要：

Purpose: Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo. Methods: Ten adult male Fischer F344 rats underwent [11C]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [11C]PK11195 between before and after injection was determined. Results: There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas. Conclusions: Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [11C]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [11C]PK11195 PET would clarify the relationships between neuroinflammation and depression. © 2018, Korean Society of Nuclear Medicine.

引用

页码：224 / 228

页数：4

共 40 条

[1]

Kunugi H., Hori H., Ogawa S., Biochemical markers subtyping major depressive disorder, Psychiatry Clin Neurosci, 69, pp. 597-608, (2015)

[2]

Pollak Y., Yirmiya R., Cytokine-induced changes in mood and behaviour: implications for 'depression due to a general medical condition', immunotherapy and antidepressive treatment, Int J Neuropsychopharmacol, 5, pp. 389-399, (2002)

[3]

Reichenberg A., Yirmiya R., Schuld A., Kraus T., Haack M., Morag A., Et al., Cytokine-associated emotional and cognitive disturbances in humans, Arch Gen Psychiatry, 58, pp. 445-452, (2001)

[4]

Martin S.A., Dantzer R., Kelley K.W., Woods J.A., Voluntary wheel running does not affect lipopolysaccharide-induced depressive-like behavior in young adult and aged mice, Neuroimmunomodulation, 21, pp. 52-63, (2014)

[5]

Sulakhiya K., Kumar P., Jangra A., Dwivedi S., Hazarika N.K., Baruah C.C., Et al., Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice, Eur J Pharmacol, 744, pp. 124-131, (2014)

[6]

Bay-Richter C., Janelidze S., Hallberg L., Brundin L., Changes in behaviour and cytokine expression upon a peripheral immune challenge, Behav Brain Res, 222, pp. 193-199, (2011)

[7]

De La Garza R., Fabrizio K.R., Radoi G.-E., Vlad T., Asnis G.M., The non-steroidal anti-inflammatory drug diclofenac sodium attenuates lipopolysaccharide-induced alterations to reward behavior and corticosterone release, Behav Brain Res, 149, pp. 77-85, (2004)

[8]

Engeland C.G., Kavaliers M., Ossenkopp K.P., Sex differences in the effects of muramyl dipeptide and lipopolysaccharide on locomotor activity and the development of behavioral tolerance in rats, Pharmacol Biochem Behav, 74, pp. 433-447, (2003)

[9]

Moraes M.M., Galvao M.C., Cabral D., Coelho C.P., Queiroz-Hazarbassanov N., Martins M.F., Et al., Propentofylline prevents sickness behavior and depressive-like behavior induced by lipopolysaccharide in rats via neuroinflammatory pathway, PLoS One, 12, (2017)

[10]

Tonelli L.H., Holmes A., Postolache T.T., Intranasal immune challenge induces sex-dependent depressive-like behavior and cytokine expression in the brain, Neuropsychopharmacology, 33, pp. 1038-1048, (2008)

← 1 2 3 4 →