Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential

被引：0
作者：
Muhammad Taha
Nor Hadiani Ismail
Waqas Jamil
Syahrul Imran
Fazal Rahim
Syed Muhammad Kashif
Mohd Zulkefeli
机构：
[1] Universiti Teknologi MARA (UiTM),Atta
[2] UiTM,ur
[3] Hazara University,Rahman Institute for Natural Product Discovery
[4] University of Sindh Jamshoro,Faculty of Applied Science
[5] Universiti Teknologi MARA (UiTM),Department of Chemistry
来源：
Medicinal Chemistry Research | 2016年 / 25卷
关键词：
2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole; Antiglycation activity; Rutin; Diabetic;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In the search of potent antidiabetic drug, we synthesized 1–25 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives. First, we synthesized 2-methoxybenzohydrazide from methyl 2-methoxybenzoate which was treated with different arylaldehydes to afford 1–25 compounds. The synthesized compounds were evaluated for antiglycation activity. We found that 1–6 and 8 showed potent activity ranging from 160.2 to 290.17 µM better than standard drug rutin (IC50 = 295.09 ± 1.04 µM). All the synthesized compounds were characterized by different spectroscopy methods. These compounds can further be studied to develop lead antidiabetic compounds.
引用
收藏
页码：225 / 234
页数：9
相关论文
共 232 条
  • [1] Ahmed N(2005)Advanced glycation endproducts—role in pathology of diabetic complications Diabetes Res Clin Pract 67 3-21
  • [2] Ahmed MS(2006)Antiglycation properties of aged garlic extract: possible role in prevention of diabetic complications J Nutr 136 796S-799S
  • [3] Ahmed N(2011)Molecular properties prediction and synthesis of novel 1,3,4-oxadiazole analogues as potent antimicrobial and antitubercular agents Bioorg Med Chem Lett 21 7246-7250
  • [4] Ahsan MJ(2012)Synthesis, antibacterial screening and hemolytic activity of S-substituted derivatives of 5-benzyl-1,3,4-oxadiazole-2-thiol Int J Pharm Pharm Sci 4 676-680
  • [5] Samy JG(2000)Evaluation of new WHO diagnostic criteria for diabetes on the prevalence of abnormal glucose tolerance in a heterogeneous Nepali population—the implications of measuring glycated hemoglobin Singapore Med J 41 264-267
  • [6] Khalilullah H(2012)Design and microwave-assisted synthesis of 1,3,4-oxadiazole derivatives for analgesic and anti-inflammatory activity J Young Pharm 4 33-37
  • [7] Nomani MS(2013)Synthesis, antimicrobial and cytotoxic activities of some novel thiazole clubbed 1,3,4-oxadiazoles Eur J Med Chem 67 54-59
  • [8] Saraswat P(2011)Synthesis, characterization and anticancer activity of certain 3-{4-(5-mercapto-1,3,4-oxadiazole-2-yl)phenylimino}indolin-2-one derivatives Saudi Pharm J 19 153-158
  • [9] Gaur R(2000)Glycation as the glucose link to diabetic complications Am Osteopath Assoc 100 621-634
  • [10] Singh A(2004)C-(β-D-Glucopyranosyl) heterocycles as potential glycogen phosphorylase inhibitors Arkivoc 7 140-149
12345678910