Comparative bioavailability of alpha-methyldopa normal and film tablet formulations after single oral administration in healthy volunteers

被引：0
|
作者：
K. Róna
K. Ary
G. Renczes
B. Gachályi
Gy. Grézal
S. Drabant
I. Klebovich
机构：
[1] Haynal Imre University of Health Sciences,1st Department of Internal Medicine, Division of Clinical Pharmacology
[2] EGIS Pharmaceuticals Ltd.,Department of Pharmacokinetics
[3] EGIS Pharmaceuticals Ltd.,Medical Division
来源：
European Journal of Drug Metabolism and Pharmacokinetics | 2001年 / 26卷
关键词：
Alpha methyldopa; pharmacokinetics; bioavailability; bioequivalence;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In a single dose, randomized, cross-over study, with one week of wash-out period, the relative bioavailability of Dopegyt® tablets containing 250 mg alpha-methyldopa (AMD) and Presinol® film tablets with identical active ingredient content was examined in 24 healthy volunteers.
引用
收藏
页码：25 / 30
页数：5
相关论文
共 50 条
  • [11] Comparative bioavailability of two sildenafil tablet formulations after single-dose administration in healthy Thai male volunteers
    Kanjanawart, S.
    Gaysonsiri, D.
    Tangsucharit, P.
    Vannaprasaht, S.
    Phunikhom, K.
    Kaewkamson, T.
    Wattanachai, N.
    Tassaneeyakul, W.
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2011, 49 (08) : 525 - 530
  • [12] Comparative bioavailability of a metoprolol controlled release formulation and a bisoprolol normal release tablet after single oral dose administration in healthy volunteers
    Deroubaix, X
    Lins, RL
    Lens, S
    Demblon, C
    Jeanbaptiste, B
    Poelaert, D
    Stockis, A
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 1996, 34 (02) : 61 - 70
  • [13] Comparative bioavailability of two cefdinir suspension formulations in middle eastern healthy volunteers after single oral administration
    Zaid, Abdel Naser
    Alhaique, Franco
    Kort, Jamal
    Sweileh, Waleed
    ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 2008, 58 (03): : 149 - 153
  • [14] Comparative bioavailability of two tablet formulations of acyclovir in healthy volunteers
    Al-Yamani, MJMS
    Al-Khamis, KI
    El-Sayed, YM
    Bawazir, SA
    Al-Rashood, KA
    Gouda, MW
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 1998, 36 (04) : 222 - 226
  • [15] A bioavailability/bioequivalence study of two oral lansoprazole formulations after single administration to healthy volunteers
    Jovanovic, D
    Kilibarda, V
    Maksimovic, M
    PHARMAZIE, 2001, 56 (10): : 800 - 802
  • [16] Comparative bioavailability of two capsule formulations of ofloxacin in healthy volunteers after a single dose administration
    Oliveira, CF
    Dias, HB
    Ribeiro, W
    Poli, A
    Peixoto, AP
    Moraes, MEA
    Moraes, MO
    Bezerra, FAF
    Moreno, H
    Muscará, MN
    de Nucci, G
    CLINICAL RESEARCH AND REGULATORY AFFAIRS, 1999, 16 (1-2) : 29 - 40
  • [17] Comparative bioavailability of two ramipril formulations after single-dose administration in healthy volunteers
    Mendes, GD
    Sanfelice, ATD
    Borges, NCD
    Cavedal, LE
    Sverdloff, C
    Galuppo, MP
    Módolo, JH
    De Nucci, G
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2006, 44 (02) : 93 - 98
  • [18] Comparative bioavailability of 4 amoxicillin formulations in healthy human volunteers after a single dose administration
    Oliveira, CH
    Abib, E
    Vannuchi, YB
    Sucupira, M
    Ilha, J
    De Nucci, G
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2001, 39 (04) : 167 - 172
  • [19] Comparative bioavailability of two losartan formulations in healthy human volunteers after a single dose administration
    Oliveira, CH
    Silva, RM
    Santagada, V
    Caliendo, G
    Perissutti, E
    Galuppo, MP
    Rezende, VM
    Barrientos-Astigarraga, RE
    Mendes, GD
    De Nucci, G
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2006, 44 (03) : 142 - 148
  • [20] Evaluation of the Bioequivalence of Two Tablet Formulations of Enalapril after Single Oral Administration to Chinese Healthy Volunteers
    Song, Ji-jun
    Gao, Jian
    Shi, Sheng-li
    Tian, Dong-dong
    Yin, Wei-yong
    LATIN AMERICAN JOURNAL OF PHARMACY, 2014, 33 (06): : 942 - 947
12345