The 2016 Nobel Prize in Chemistry highlighted another spectacular achievement in structural chemistry and supramolecular chemistry. The three awardees built molecular machines based on their intimate knowledge of molecular properties and behavior. One of the three laureates, J. Fraser Stoddart, with two co-authors, published an invited paper in 1999 in our journal in which they surveyed the interplay between the synthesis of functioning supramolecular systems and their X-ray crystallographic investigation. Structural Chemistry congratulates Stoddart and his co-laureates on this momentous occasion.