LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

被引：0

作者：

Jan J Molenaar

Raquel Domingo-Fernández

Marli E Ebus

Sven Lindner

Jan Koster

Ksenija Drabek

Pieter Mestdagh

Peter van Sluis

Linda J Valentijn

Johan van Nes

Marloes Broekmans

Franciska Haneveld

Richard Volckmann

Isabella Bray

Lukas Heukamp

Annika Sprüssel

Theresa Thor

Kristina Kieckbusch

Ludger Klein-Hitpass

Matthias Fischer

Jo Vandesompele

Alexander Schramm

Max M van Noesel

Luigi Varesio

Frank Speleman

Angelika Eggert

Raymond L Stallings

Huib N Caron

Rogier Versteeg

Johannes H Schulte

机构：

[1] Academic Medical Center,Department of Oncogenomics

[2] Royal College of Surgeons in Ireland,Department of Molecular and Cellular Therapeutics

[3] National Children's Research Centre,Department of Pediatric Oncology and Haematology

[4] Children's Hospital Essen,Department of Pediatric Oncology and Hematology

[5] Center for Medical Genetics,Department of Pediatric Oncology/Hematology

[6] Ghent University,undefined

[7] Institute of Pathology,undefined

[8] University Hospital Cologne,undefined

[9] Institute of Cell Biology,undefined

[10] University Hospital Essen,undefined

[11] Children's Hospital,undefined

[12] University of Cologne,undefined

[13] Erasmus Medical Centre–Sophia Children's Hospital,undefined

[14] Laboratory of Molecular Biology,undefined

[15] Gaslini Institute,undefined

来源：

Nature Genetics | 2012年 / 44卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Jan Molenaar and colleagues show that LIN28B is overexpressed and amplified in human neuroblastomas and that LIN28B regulates let-7 family miRNAs and MYCN. They create a transgenic mouse model of LIN28B overexpression and show that these mice develop neuroblastoma tumors.

引用

页码：1199 / 1206

页数：7

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