Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer

被引:0
|
作者
Sriganesh Srihari
Jitin Singla
Limsoon Wong
Mark A. Ragan
机构
[1] The University of Queensland,Institute for Molecular Bioscience
[2] Indian Institute of Technology Roorkee,Department of Computer Science and Engineering
[3] National University of Singapore,Department of Computer Science
来源
关键词
Synthetic lethality; Mutual exclusivity; Context-dependent genetic vulnerabilities; Context-dependent oncogenes;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [1] Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer
    Srihari, Sriganesh
    Singla, Jitin
    Wong, Limsoon
    Ragan, Mark A.
    BIOLOGY DIRECT, 2015, 10
  • [2] Synthetic Lethal Interactions of MDS-Associated Spliceosomal Gene Mutations Identifies the Basis for Their Mutual Exclusivity
    Lee, Stanley Chun-Wei
    Dilai, Khrystyna
    Obeng, Esther A.
    Kim, Eunhee
    Micol, Jean-Baptiste
    Yoshimi, Akihide
    Willekens, Christophe
    Inoue, Daichi
    Saada, Veronique
    Cho, Hana
    Chung, Young Rock
    Palacino, James
    Seiler, Michael
    Buonamici, Silvia
    Smith, Peter
    Ebert, Benjamin L.
    Bradley, Robert
    Abdel-Wahab, Omar
    BLOOD, 2016, 128 (22)
  • [3] Identifying actionable synthetically lethal cancer gene pairs using mutual exclusivity
    Wooller, Sarah K.
    Pearl, Laurence H.
    Pearl, Frances M. G.
    FEBS LETTERS, 2024, 598 (16) : 2028 - 2039
  • [4] Synthetic Lethal Interactions in Cancer Therapy
    Geng, Xinwei
    Wang, Xiaohui
    Zhu, Dan
    Ying, Songmin
    CURRENT CANCER DRUG TARGETS, 2017, 17 (04) : 304 - 310
  • [5] Inferring the function of genes from synthetic lethal mutations
    Ray, O.
    Bryant, C. H.
    CISIS 2008: THE SECOND INTERNATIONAL CONFERENCE ON COMPLEX, INTELLIGENT AND SOFTWARE INTENSIVE SYSTEMS, PROCEEDINGS, 2008, : 667 - +
  • [6] Chemical-genetic Screenings for Synthetic-lethal Interactions in Breast Cancer
    Soncini, D.
    Caffa, I.
    Zoppoli, G.
    Petrone, F.
    Ballestrero, A.
    Nencioni, A.
    EUROPEAN JOURNAL OF CANCER, 2011, 47 : S151 - S151
  • [7] Predicting Synthetic Lethal Genetic Interactions in Breast Cancer using Decision Tree
    Yin, Zibo
    Qian, Bowen
    Yang, Guowei
    Guo, Li
    ICBBE 2019: 2019 6TH INTERNATIONAL CONFERENCE ON BIOMEDICAL AND BIOINFORMATICS ENGINEERING, 2019, : 1 - 6
  • [8] Understanding and predicting synthetic lethal genetic interactions in Saccharomyces cerevisiae using domain genetic interactions
    Li, Bo
    Cao, Weiguo
    Zhou, Jizhong
    Luo, Feng
    BMC SYSTEMS BIOLOGY, 2011, 5
  • [9] Systematic interrogation of cancer dependencies and synthetic lethal interactions
    Hahn, William C.
    CANCER RESEARCH, 2019, 79 (13)
  • [10] Exploiting synthetic lethal interactions for targeted cancer therapy
    Reinhardt, H. Christian
    Jiang, Hai
    Hemann, Michael T.
    Yaffe, Michael B.
    CELL CYCLE, 2009, 8 (19) : 3112 - 3119