Life-threatening capillary leak syndrome after G-CSF mobilization and collection of peripheral blood progenitor cells for allogeneic transplantation

被引:0
作者
AM de Azevedo
D Goldberg Tabak
机构
[1] Centro Nacional de Transplante de Medula Óssea,
[2] CEMO,undefined
[3] Instituto Nacional de Câncer,undefined
[4] INCA,undefined
来源
Bone Marrow Transplantation | 2001年 / 28卷
关键词
G-CSF; capillary leak syndrome; leukapheresis; peripheral blood progenitor cell transplantation;
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学科分类号
摘要
We report a case of capillary leak syndrome in a 37-year-old female PBPC donor who received G-CSF 900 μg/day for 4 days and underwent leukapheresis. This lady had remained well and stable despite marked leukocytosis during G-CSF treatment, but developed hypotension during leukapheresis, quickly followed by hypoxemia, ascites, pericardial and pleural effusion, shock, edema, neurologic changes and hepatocellular injury. Upon G-CSF withdrawal, dopamine and crystalloid infusion, methylprednisolone treatment and suspension of apheresis, the clinical situation fully reversed. We hypothesize that leukapheresis, in the presence of marked leukocytosis and high doses of G-CSF, may have triggered neutrophil activation and the release of inflammatory mediators, resulting in tissue damage and systemic manifestations of increased capillary permeability. Bone Marrow Transplantation (2001) 28, 311–312.
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页码:311 / 312
页数:1
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