Comparison of mutagenic activities of various ultra-fine particles

被引：21
作者：
Park C.G. [1 ]
Cho H.K. [1 ]
Shin H.J. [2 ]
Park K.H. [3 ]
Lim H.B. [1 ]
机构：
[1] College of Agriculture, Life and Environment Sciences, Chungbuk National University, Cheongju
[2] KTandG Research Institute, Daejeon
[3] National Leading Research Laboratory (Aerosol Technology and Monitoring Laboratory), School of Environmental Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju
来源：
Toxicological Research | 2018年 / 34卷 / 2期
关键词：
Air pollution; Ames test; Mutagenicity; Ultra-fine particle;
D O I：
10.5487/TR.2018.34.2.163
中图分类号：
学科分类号：
摘要：
Air pollution is increasing, along with consumption of fossil fuels such as coal and diesel gas. Air pollutants are known to be a major cause of respiratory-related illness and death, however, there are few reports on the genotoxic characterization of diverse air pollutants in Korea. In this study, we investigated the mutagenic activity of various particles such as diesel exhaust particles (DEP), combustion of rice straw (RSC), pine stem (PSC), and coal (CC), tunnel dust (TD), and road side dust (RD). Ultra-fine particles (UFPs) were collected by the glass fiber filter pad. Then, we performed a chemical analysis to see each of the component features of each particulate matter. The mutagenicity of various UFPs was determined by the Ames test with four Salmonella typhimurium strains with or without metabolic activation. The optimal concentrations of UFPs were selected based on result of a concentration decision test. Moreover, in order to compare relative mutagenicity among UFPs, we selected and tested DEP as mutation reference. DEP, RSC, and PSC induced concentration-dependent increases in revertant colony numbers with TA98, TA100, and TA1537 strains in the absence and presence of metabolic activation. DEP showed the highest specific activity among the particulate matters. In this study, we conclude that DEP, RSC, PSC, and TD displayed varying degrees of mutagenicity, and these results suggest that the mutagenicity of these air pollutants is associated with the presence of polycyclic aromatic hydrocarbons (PAHs) in these particulate matters. © 2018, Korean Society of Toxicology.
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页码：163 / 172
页数：9
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